A Canadian study investigating the expansion of umbilical cord blood stem cells has advanced into early clinical trial stages.<\/p>\n
The news comes after scientists reported promising initial results, which found that expanded cells could facilitate even\u00a0faster recoveries than conventional transplants.<\/p>\n
Led by haematologist Dr Sandra Cohen from Maisonneuve-Rosemont Hospital in Montreal, researchers will now apply their multiple cord blood samples in a greater amount of human transplants.<\/p>\n
Cord blood expansion is the process of multiplying the cells within a sample to increase treatment possibilities.<\/p>\n
This can be done in three ways:<\/p>\n
Umbilical cord blood, and the stem cells it contains, has already been used in more than 35,000 transplants worldwide.<\/p>\n
Cord blood is often preferred for transplants because it presents a lower risk of compatibility issues than other types of blood or stem cells.<\/p>\n
However, cord blood typically has a smaller stem cell count than other sources such as bone marrow or adipose. Because of this, an umbilical cord sample is sometimes too small for a successful adult transplant.<\/p>\n
Scientists are therefore eager to expand cord blood to resolve this issue and help thousands of people waiting for transplants around the world.<\/p>\n
In the new clinical trial, researchers will use a small molecule called UM171 to multiply cord blood samples.<\/p>\n
UM171 binds to a sample and prevents new blood cells from differentiating into more specific cell types. Instead, they remain in their stem cell form and proliferate.<\/p>\n
Over the course of seven days, UM171 can multiply stem cells by up to 35 times.<\/p>\n
Once transplanted, the stem cells transform into different cell types that can restore and regenerate damaged or diseased areas of the body.<\/p>\n
Although the trial is only just entering clinical trial stages, results from the initial study have been extremely promising.<\/p>\n
After 12 months, the survival rate was at 75% for patients who received the expanded cord blood. With a conventional cord blood transplant, success rates stand at around 60%.<\/p>\n
Cord blood expansion should be a particularly exciting prospect for parents who have banked – or are thinking of banking \u2013 baby stem cells. Multiplying a sample increases treatment opportunities, and gives families more freedom to make the most of their baby\u2019s cord blood.<\/p>\n
Our unique Cells<\/strong>Plus<\/em><\/strong> service has also been designed with cell count in mind, retaining 3 times more stem cells than any other cord blood processing system.<\/p>\n Find out more about CellsPlus<\/a>.<\/p>\n Sources:<\/strong><\/p>\n https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02668315<\/a> All you need to know to make an informed decision.<\/p>\n Provide your contact details to request:<\/p>\n – Complete Welcome Pack and Parent\u2019s Guide <\/p>\n\n <\/p>
https:\/\/globenewswire.com\/news-release\/2018\/06\/27\/1530329\/0\/en\/Final-patient-receives-treatment-in-stem-cell-clinical-trial-for-severe-blood-cancers.html<\/a>
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