{"id":12777,"date":"2021-04-11T06:04:11","date_gmt":"2021-04-11T06:04:11","guid":{"rendered":"https:\/\/cells4life.com\/?p=12777"},"modified":"2023-08-09T12:52:50","modified_gmt":"2023-08-09T12:52:50","slug":"stem-cell-therapy-for-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2021\/04\/stem-cell-therapy-for-parkinsons-disease\/","title":{"rendered":"Stem cell therapy for Parkinson’s disease"},"content":{"rendered":"[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]\n

Researchers at Kyoto University\u2019s Centre for iPS Cell Research and Application<\/em> in Japan are moving ahead with the world\u2019s first application of induced pluripotent stem cells (iPSCs) to treat Parkinson\u2019s disease.<\/p>\n

The team, led by neurosurgeon Jun Takahashi, will now engage in a limited clinical trial to test the potential side effects.<\/p>\n

Osaka based drug maker Sumitomo Dainippon Pharma Co Ltd has lined itself up to manufacture and start selling cellular medicine based on the data from these clinical trials by 2023.<\/span><\/p>\n

This development comes as a number of clinical trials of iPS cell-based treatments are underway worldwide.<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]\n

What is Parkinson\u2019s disease?<\/h3>\n

Parkinson\u2019s is a progressive neurological condition marked by tremors, muscular rigidity, and slow, imprecise movement.<\/p>\n

This condition falls under “movement disorders” such as Cerebral Palsy<\/a>, Ataxia, Huntington’s disease and many more which are know to worsen with time.<\/p>\n

The treatment<\/h3>\n

Treatment will see scientists take iPSCs from healthy people, match them with patients, then induce the cells to become dopaminergic progenitors.<\/p>\n

These progenitors will then be injected into a brain region \u2013 called the \u201cputamen\u201d \u2013 that is known to have a major part in the neural degeneration linked with Parkinson\u2019s disease.<\/p>\n

More than 5 million cells will be transplanted into patients then left to develop into neurons. These neurons can replace the dopamine lost due to the effects of Parkinson\u2019s.<\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ background_color=”#00abc9″ background_layout=”dark” custom_padding=”10px|10px|10px|10px” border_radii=”on|5px|5px|5px|5px” global_colors_info=”{}”]\n

What is dopamine?<\/h4>\n

Dopamine is a neurotransmitter responsible for transmitting signals between nerve cells (neurons) in the brain. <\/p>\n

Very few neurons make dopamine, and Parkinson\u2019s disease leads to the death of many of those that do. <\/p>\n

The decline in dopamine levels leads to Parkinson\u2019s disease symptoms, such as shaking and loss of motor function.
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]\n

The impact<\/h3>\n

The new treatment is not a cure for Parkinson\u2019s disease and there is no apparent effect on damaged cognitive function.
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]However, it could offer a potentially longer-term treatment for the disease. Currently, patients with Parkinson\u2019s receive oral dopamine medication but the benefits start to dwindle after about a decade. <\/p>\n

Scientists have already engaged in a successful pre-clinical study using monkeys, which found that stem cell transplantation greatly improved motor function in the event of Parkinson\u2019s disease. <\/p>\n

Historically, there has been some concern that iPSCs cells could create cancer-forming cells but the test monkeys did not develop any malignant tumours within two years of their transplant.
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About Parkinson’s<\/h4>\n