Cord blood transfusion<\/strong><\/h4>\nCord blood transfusions use blood collected from the umbilical cord at the time of birth to introduce healthy cells into the patient\u2019s blood system.<\/p>\n
Unlike bone marrow transplantation, cord blood transfusions are more successful when they are delivered before symptoms appear.
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” column_structure=”1_3,2_3″][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ background_color=”#009fc4″ background_layout=”dark” custom_padding=”15px|15px|15px|15px” global_colors_info=”{}”]\n
\u201cOur study provides evidence that the youngest babies who are at risk of developing the most severe form of Krabbe disease should be strongly considered for HSCT as soon as possible. HSCT, like all surgical procedures, does carry some risks so parents may be inclined to wait until Krabbe symptoms develop, but our findings suggest that may be too late for the best outcomes.\u201d<\/h5>\n
Dr Maria Escolar\u00a0<\/strong>
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]\nWhat did the trial involve?<\/strong><\/h3>\nDr Escolar\u2019s study treated 18 children with cord blood transfusions within 7 weeks of their birth.<\/p>\n
Children were chosen based on a high risk of developing early-onset Krabbe disease, based on family history and genetic screening.<\/p>\n
After transfusion, researchers followed the children\u2019s progress for up to 15 years. This involved comprehensive annual evaluations of cognitive, speech and motor function, tests to determine the speed and strength of electrical signals from peripheral nerves, as well as brain imaging.<\/p>\n
Intervention is most effective when done before symptoms appear and may help children live at least til their teens<\/p>\n
What were the results?<\/strong><\/h3>\nIn 2005, Dr Escolar\u2019s research showed that haematopoietic stem cell transplants had at least three years of benefits.<\/p>\n
This most recent study showed that early treatment of Krabbe disease with cord blood could improve quality of life and lead to longer lifespans.<\/p>\n
The majority of the 18 children saw continued improvement in their motor, cognitive and language skills \u2013 even though these would usually degrade as the disease progresses.<\/p>\n
10 of 18 children can now walk – two of whom can walk independently.
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/cells4life.com\/us\/wp-content\/uploads\/2018\/10\/Krabbe_disease_infographic.jpg” align_tablet=”center” align_last_edited=”on|desktop” _builder_version=”4.16″ always_center_on_mobile=”on” global_colors_info=”{}” align_phone=”center”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”#bd144f” custom_padding=”0px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row padding_mobile=”on” column_padding_mobile=”on” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”0px|20px” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_image src=”https:\/\/cells4life.com\/us\/wp-content\/uploads\/2015\/09\/section-divider11.png” align=”center” align_tablet=”center” align_last_edited=”on|desktop” _builder_version=”4.16″ animation_style=”slide” animation_direction=”top” animation_duration=”500ms” animation_intensity_slide=”10%” use_border_color=”off” border_color=”#ffffff” border_style=”solid” animation=”top” sticky=”off” global_colors_info=”{}” theme_builder_area=”post_content” align_phone=”center”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text admin_label=”RWP” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” use_border_color=”off” global_colors_info=”{}” theme_builder_area=”post_content”]\n
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