{"id":15762,"date":"2019-03-12T15:51:18","date_gmt":"2019-03-12T15:51:18","guid":{"rendered":"https:\/\/cells4life.com\/?p=15762"},"modified":"2019-07-19T16:28:23","modified_gmt":"2019-07-19T16:28:23","slug":"mesenchymal-stem-cells-treat-sepsis","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2019\/03\/mesenchymal-stem-cells-treat-sepsis\/","title":{"rendered":"Mesenchymal stem cells treat sepsis"},"content":{"rendered":"[et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221;][et_pb_row][et_pb_column type=&#8221;4_4&#8243;][et_pb_text _builder_version=&#8221;3.17.2&#8243; background_color=&#8221;#009fc4&#8243; text_font=&#8221;|300|||||||&#8221; text_font_size=&#8221;20px&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;20px|20px|20px|20px&#8221;]\n<p><strong><a style=\"color: #fff;\" href=\"https:\/\/cells4life.com\/cord-blood-banking-overview\/stem-cell-treatments\/\">Stem cell therapy<\/a><\/strong> has the potential to cure sepsis, according to a team of scientists in Durham, North Carolina.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;3_5&#8243;][et_pb_text _builder_version=&#8221;3.17.2&#8243;]\n<h3><strong>What is sepsis and how do you get it?<\/strong><\/h3>\n<p>Sepsis is a condition that occurs when the body\u2019s normal response to infection goes into overdrive and causes organ dysfunction.<\/p>\n<p>It is usually caused by infection. A relatively common illness such as a skin infection or pneumonia could trigger the condition.<\/p>\n<p>When this happens, the body\u2019s immune system can become overwhelmed by infection and responds with an excessive inflammatory response. This inflammation spreads and affects otherwise healthy tissue and organs.<\/p>\n<h3><strong>Who is most at risk of contracting sepsis?<\/strong><\/h3>\n<p>Sepsis is a major cause of death in premature babies, but it can affect people of all ages.<\/p>\n<h3><strong>What are the signs of sepsis?<\/strong><\/h3>\n<p>The signs of sepsis vary between newborns and adults, but generally include weakness, loss of appetite as well as fever and chills.<\/p>\n<p>In babies, you can also look out for a heart rate above 90 BPM, and a breathing rate above 20 breathes per minute. It is worth keeping an eye out for these signs when an infection first begins.<\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243;][et_pb_text _builder_version=&#8221;3.17.2&#8243; background_color=&#8221;#bd144f&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;20px|20px|20px|20px&#8221;]\n<h3><strong>The three stages of sepsis<\/strong><\/h3>\n<h4><strong>Stage 1<\/strong><\/h4>\n<ul>\n<li>A part of the body becomes infected<\/li>\n<li>Germs and toxins produced by the bacteria or virus enter the bloodstream<\/li>\n<li>This initiates an inflammatory response.<\/li>\n<\/ul>\n<h4><strong>Stage 2 <\/strong><\/h4>\n<ul>\n<li>Individual organs in the body become affected.<\/li>\n<li>They deteriorate and in some cases, fail.<\/li>\n<\/ul>\n<h4><strong>Stage 3 <\/strong><\/h4>\n<ul>\n<li>In severe cases, multiple organs stop functioning<\/li>\n<li>The patient experiences cardio-circulatory failure<\/li>\n<li>A rapid drop in blood pressure occurs, called \u201cseptic shock\u201d.<\/li>\n<\/ul>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;3_5&#8243;][et_pb_text _builder_version=&#8221;3.17.2&#8243;]\n<h3><strong>What is the cure for sepsis? <\/strong><\/h3>\n<p>Currently, doctors treat sepsis with a course of antibiotics, but doctors worry that the increasing likelihood of antibiotic resistance will render this treatment inert.<\/p>\n<p>The clinical study, spearheaded by Desiree Perlee from The University of Arizona Medical Center, aims to use stem cells as a potential cure for the condition.<\/p>\n<p>In the trial, researchers gave 32 volunteers a drug to induce endotoxemia, a form of bacterial inflammation that has similar characteristics to sepsis and can therefore be used as a stand-in.<\/p>\n<p>After an hour, doctors gave patients an infusion of allogeneic mesenchymal stem cells (ACSs), <a href=\"https:\/\/cells4life.com\/cord-blood-banking-overview\/about-umbilical-cord-blood\/\">which can be found in the umbilical cord<\/a>.<\/p>\n<p>The results showed that these stem cells were well tolerated and at the highest dose, had promising anti-inflammatory effects as well as a mild pro-coagulant impact.<\/p>\n<p>However, researchers noted that endotoxemia may respond differently to treatment and researchers need to investigate further in sepsis patients.<\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243;][et_pb_text _builder_version=&#8221;3.17.2&#8243; background_color=&#8221;#bd144f&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;20px|20px|0px|20px&#8221;]\n<ul>\n<li>\n<h4>Sepsis kills 1 in every 4 patients who contract it<\/h4>\n<\/li>\n<li>\n<h4>It affects 250,000 children each year in the UK<\/h4>\n<\/li>\n<li>\n<h4>Kills 5 people every hour<\/h4>\n<\/li>\n<li>\n<h4>44,000 deaths per year \u2013 more than bowel, breast and prostate cancer combined<\/h4>\n<\/li>\n<li>\n<h4>6 million death toll worldwide<\/h4>\n<\/li>\n<li>\n<h4>30 million cases of sepsis globally<\/h4>\n<\/li>\n<\/ul>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;4_4&#8243;][et_pb_text _builder_version=&#8221;3.17.2&#8243;]\n<h3><strong>Stem cells and inflammation<\/strong><\/h3>\n<p>This trial is just the latest attempting to harness the anti-inflammatory power of stem cells to treat a life-threatening condition. Scientists are also <a href=\"https:\/\/cells4life.com\/2018\/08\/treating-alzheimers-with-stem-cells-found-in-fat\/\">exploring MSCs for the treatment of Alzheimer\u2019s<\/a>.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;RWP Blog&#8221; _builder_version=&#8221;3.17.2&#8243;][et_pb_column type=&#8221;4_4&#8243;][et_pb_text _builder_version=&#8221;3.17.2&#8243; background_color=&#8221;#bd114f&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;20px|20px|20px|20px&#8221;]\n<h2 style=\"text-align: center;\">Request a Welcome Pack<\/h2>\n<p style=\"text-align: center;\">Find out more about cord blood banking by downloading a Welcome Pack now.<\/p>\n\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f14118-o1\" lang=\"en-US\" dir=\"ltr\" data-wpcf7-id=\"14118\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/us\/wp-json\/wp\/v2\/posts\/15762#wpcf7-f14118-o1\" 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aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_row et_pb_row_0 et_pb_row_empty\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> Stem cell therapy has the potential to cure sepsis, according to a team of scientists in Durham, North Carolina. <div class=\"et_pb_row et_pb_row_1 et_pb_row_empty\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> What is sepsis and how do you get it? Sepsis is a condition that occurs when the body\u2019s normal response to infection goes into overdrive and causes organ dysfunction. It is usually caused by [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":16137,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[55],"tags":[],"class_list":["post-15762","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/15762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/comments?post=15762"}],"version-history":[{"count":6,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/15762\/revisions"}],"predecessor-version":[{"id":16144,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/15762\/revisions\/16144"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media\/16137"}],"wp:attachment":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media?parent=15762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/categories?post=15762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/tags?post=15762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}