{"id":31904,"date":"2024-02-21T10:57:23","date_gmt":"2024-02-21T10:57:23","guid":{"rendered":"https:\/\/cells4life.com\/?p=31904"},"modified":"2025-11-25T15:29:51","modified_gmt":"2025-11-25T15:29:51","slug":"stem-cells-grow-heart-in-a-dish-heart-disease-breakthrough","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2024\/02\/stem-cells-grow-heart-in-a-dish-heart-disease-breakthrough\/","title":{"rendered":"Stem Cells Used to Grow &#8216;Heart in a Dish&#8217;: Hailed as Heart Disease Breakthrough"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]\n<p class=\"ai-optimize-57\"><span style=\"font-weight: 400;\">It was announced this week that researchers at the University of East London had managed to grow a \u201cheart\u201d using stem cells.<\/span><\/p>\n<p class=\"ai-optimize-58\"><span style=\"font-weight: 400;\">This breakthrough could be instrumental in paving the way for life-saving research into heart disease treatments, with stem cells playing a pivotal role in the future of cardiovascular research.<\/span><\/p>\n<p class=\"ai-optimize-59\"><span style=\"font-weight: 400;\">According to the Centers for Disease Control and Prevention, heart disease remains the leading cause of death in the United States. In 2023 alone, 919,032 people died from cardiovascular disease. That\u2019s one person every 34 seconds.<\/span><\/p>\n<p class=\"ai-optimize-60\"><span style=\"font-weight: 400;\">With coronary artery disease alone affecting around 1 in 20 adults, progress in cardiovascular medicine can\u2019t come soon enough. <\/span><a href=\"https:\/\/www.cdc.gov\/heart-disease\/data-research\/facts-stats\/index.html\" target=\"_blank\" rel=\"noopener\"><span>[1]<\/span><\/a><\/p>\n<p class=\"ai-optimize-62\"><span style=\"font-weight: 400;\">Because the grown stem cell \u201cheart\u201d has the same characteristics as a normal human heart, scientists are hoping that it can be a more ethical, accurate alternative to the use of animal specimens in research.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-63\"><span style=\"font-weight: 400;\">This is the latest development in a long line of investigations into the application of stem cells to grow heart tissue.<\/span><\/p>\n<p class=\"ai-optimize-64\"><span style=\"font-weight: 400;\">Last April, researchers at the Francis Crick Institute and Imperial College London set about evaluating how human pluripotent stem cells (hPSCs) could be used to grow left ventricular heart muscle cells. <\/span><a href=\"https:\/\/www.imperial.ac.uk\/news\/244579\/heartbeat-dish-growing-specialised-heart-cells\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2]<\/span><\/a><\/p>\n<p class=\"ai-optimize-65\"><span style=\"font-weight: 400;\">Their findings suggested that, with the right environment, stem cells are able to differentiate successfully into the cells that make up the left ventricle of the heart, the area most commonly affected by heart disease <\/span><a href=\"https:\/\/www.cell.com\/cell-reports-methods\/fulltext\/S2667-2375(23)00075-9\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3]<\/span><\/a><\/p>\n<p class=\"ai-optimize-66\"><span style=\"font-weight: 400;\">In August of last year, a team of researchers from various Israeli institutions had grown a small, yet complete and beating, model of a heart using stem cells. They were even able to fit sensors to the model to monitor its behavior. <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41551-023-01071-9\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4]<\/span><\/a><\/p>\n<p class=\"ai-optimize-67\"><span style=\"font-weight: 400;\">These so-called organoid hearts, grown from stem cells, are incredibly useful in finding treatments and therapies for cardiovascular diseases because of their likeness to human hearts.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-68\"><span style=\"font-weight: 400;\">Although these \u201cgrown\u201d hearts are a lot smaller than human hearts, their construction and makeup reflects the different chambers, tissues and cells that make up a human heart far more accurately. This makes them better in experiments for developing medicine for heart disease than animal samples.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-69\"><span style=\"font-weight: 400;\">The team at The University of East London are also looking to develop an AI in conjunction with the stem cell heart to monitor intricate changes to cells that could indicate the onset of heart disease. <\/span><a href=\"https:\/\/www.standard.co.uk\/news\/health\/university-east-london-scientists-heart-dish-stem-cells-b1139981.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5]<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p class=\"ai-optimize-70\"><span style=\"font-weight: 400;\">With thousands of clinical trials currently underway for the application of cord blood and perinatal stem cells in regenerative medicine, it\u2019s possible that your baby\u2019s umbilical cord and placenta hold the key to unlocking their access to the treatments of the future.<\/span><\/p>\n<p class=\"ai-optimize-71\"><span style=\"font-weight: 400;\">Find out more about how storing your baby\u2019s stem cells could safeguard their health for life by downloading our FREE Info Kit below.<\/span><\/p>\n<p class=\"ai-optimize-72\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p class=\"ai-optimize-73\"><b>Sources<\/b><\/p>\n<p class=\"ai-optimize-74\"><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.cdc.gov\/heart-disease\/data-research\/facts-stats\/index.html\" target=\"_blank\" rel=\"noopener\">[1] CDH International. (n.d.). <em data-start=\"81\" data-end=\"97\">CDH statistics<\/em> [Webpage]. Retrieved October 30, 2025, from<\/a> <a class=\"decorated-link\" href=\"https:\/\/www.cdc.gov\/heart-disease\/data-research\/facts-stats\/index.html\" target=\"_new\" rel=\"noopener\" data-start=\"142\" data-end=\"174\">https:\/\/www.cdc.gov\/heart-disease\/data-research\/facts-stats\/index.html<\/a><\/span><\/p>\n<p class=\"ai-optimize-75\"><a href=\"https:\/\/www.imperial.ac.uk\/news\/244579\/heartbeat-dish-growing-specialised-heart-cells\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2] <\/span><span style=\"font-weight: 400;\">Ingham, K. (2023, April 26). <\/span><i><span style=\"font-weight: 400;\">A heartbeat in a dish \u2013 growing specialised heart cells<\/span><\/i><span style=\"font-weight: 400;\">. Imperial College London. https:\/\/www.imperial.ac.uk\/news\/244579\/heartbeat-dish-growing-specialised-heart-cells\/<\/span><\/a><\/p>\n<p class=\"ai-optimize-76\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2667237523000759?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3] Nicola Dark, <\/span><i><span style=\"font-weight: 400;\">et al<\/span><\/i><span style=\"font-weight: 400;\">., Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells, Cell Reports Methods, Volume 3, Issue 4, 2023, 100456, ISSN 2667-2375<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p class=\"ai-optimize-77\"><a href=\"https:\/\/www.nature.com\/articles\/s41551-023-01071-9#citeas\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4] Ghosheh, M., Ehrlich, A., Ioannidis, K. et al. Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids. Nat. Biomed. Eng 7, 1493\u20131513 (2023)<\/span><\/a><\/p>\n<p class=\"ai-optimize-78\"><a href=\"https:\/\/www.standard.co.uk\/news\/health\/university-east-london-scientists-heart-dish-stem-cells-b1139981.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5] Keane, D. (2024, February 19). <\/span><i><span style=\"font-weight: 400;\">Heart disease breakthrough as scientists grow &#8216;heart in a dish&#8217; using stem cells in London lab<\/span><\/i><span style=\"font-weight: 400;\">. The Standard. https:\/\/www.standard.co.uk\/news\/health\/university-east-london-scientists-heart-dish-stem-cells-b1139981.html<\/span><\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;down-arrow&#8221; _builder_version=&#8221;4.27.4&#8243; background_color=&#8221;#bd144f&#8221; custom_padding=&#8221;0px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;RWP&#8221; module_id=&#8221;request-welcome-pack&#8221; _builder_version=&#8221;4.27.4&#8243; 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aria-invalid=\"false\" placeholder=\"Country\" value=\"\" type=\"text\" name=\"primary_address_country\" \/><\/span>\n<\/p>\n<p><input class=\"wpcf7-form-control wpcf7-submit has-spinner wpcf7-button c4l-button-dark gtm-rwp-onpage\" type=\"submit\" value=\"REQUEST\" \/>\n<\/p>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"us\" type=\"hidden\" name=\"webform_site_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"true\" type=\"hidden\" name=\"sugar_crm_lead\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"76dbb9e8-4c86-d341-0772-689602ea5afc\" type=\"hidden\" name=\"campaign_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"assigned_user_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"created_by\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"rwp\" type=\"hidden\" name=\"lead_source\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{EXT_REFERER}\" type=\"hidden\" name=\"webform_referrer_url_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{COOKIE:_#uid}\" type=\"hidden\" name=\"webform_contact_id_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"request-welcome-pack\" type=\"hidden\" name=\"originating_web_form_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{IP_ADDRESS}\" type=\"hidden\" name=\"webform_ip_address_c\" \/><input type='hidden' class='wpcf7-pum' value='{\"closepopup\":false,\"closedelay\":0,\"openpopup\":false,\"openpopup_id\":0}' \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>It was announced this week that researchers at the University of East London had managed to grow a \u201cheart\u201d using stem cells. This breakthrough could be instrumental in paving the way for life-saving research into heart disease treatments, with stem cells playing a pivotal role in the future of cardiovascular research. According to the Centers [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":31908,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>Most people know what it\u2019s like to feel sadness. But when feeling down persists for weeks, or even months, it can be a sign of a mental health condition, like depression.<\/p><p>Although today people are well versed and more understanding of depression, some sufferers still find it difficult to find treatments.<\/p><h3>What is depression?<\/h3><p>Depression is a common mental health condition. It is characterised by low mood, feelings of hopelessness, losing interest in things which previously brought a sense of enjoyment, and feeling tearful.<\/p><p>Depression can also manifest in physical ways. Sleeping poorly, feeling tired, experiencing aches, pains, a diminished appetite, and decreased libido can all be impacts of depression. The symptoms range from mild to severe. In mild cases, a persistent low mood may be the cause, while severe cases may result in suicidal feelings or a desire to self harm <a href=\"https:\/\/www.nhs.uk\/mental-health\/conditions\/depression-in-adults\/overview\/\">[1]<\/a>.<\/p><p>Sometimes the causes of depression can be obvious, such as a bereavement or a traumatic event. Other times there might be no known cause, although family history could be the reason. Whatever the reason, once a person has identified they may be depressed, they should go and see their GP.<\/p><h3>What treatments are available?<\/h3><p>There are a plethora of treatments for depression that a doctor can prescribe, from talking therapies to pharmaceutical medications to exercise and more. Sometimes the GP may recommend one treatment or a combination of treatments but they will help support patients and signpost them to services which can bolster their support network.<\/p><p>The good news is that depression is among the most treatable mental health disorders.\u00a0 Between 80% and 90% percent of people with depression eventually respond well to treatment. Almost all patients gain some relief from their symptoms <a href=\"https:\/\/www.psychiatry.org\/patients-families\/depression\/what-is-depression#:~:text=Depression%20is%20among%20the%20most,some%20relief%20from%20their%20symptoms.\">[2]<\/a>.<\/p><h3>Treatment Resistant Depression<\/h3><p>For those with major depressive disorder, however, treatment can be harder to find. With up to one third of adults with the condition failing to respond to treatment, new avenues and treatments are being sought.<\/p><p>\u201cAlthough there is some disagreement as to how to define treatment-resistant depression, a patient is generally considered to have it if the individual hasn\u2019t responded to adequate doses of two different antidepressants taken for a sufficient duration of time, which is usually six weeks,\u201d explains Jaskaran Singh, M.D., Senior Director of Neuroscience, Janssen Pharmaceuticals <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[3]<\/a>.<\/p><p>The theory that depression may have causes currently unknown by scientists is one theory researchers are exploring to try and combat resistance to treatment.<\/p><p>\u201cOne of the more modern theories is that depression creates inflammation in the brain, or that inflammation in the brain creates depression. Traditional antidepressants only affect neurotransmitters, so this may be why some patients don\u2019t respond to them.\u201d\u00a0 says Alexander Papp, M.D., a psychiatrist at UC San Diego Health <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[4]<\/a>.<\/p><p>Whether or not this is the case, researchers are still trying to find solutions to Treatment Resistant Depression.<\/p><h3>The Potential of Cord Blood Therapy<\/h3><p>One study using umbilical cord blood cells delivered promising results. The study administered concentrated umbilical cord blood cells at a dose of 250 million cells via weekly injections over 4 weeks with 1 week intervals, to women who suffered with Treatment Resistant Depression.\u00a0 The results were tested against a control group who received a placebo.<\/p><p>The study found that the therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7087609\/\">[5]<\/a>. Other studies have also found that cellular therapies may have a role in combating Treatment Resistant Depression <a href=\"https:\/\/www.mdpi.com\/1999-4923\/15\/3\/814\">[6]<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8474995\/\">[7]<\/a>.<\/p><p>These studies give hope for finding new treatments. With the help of umbilical cord blood cells, those suffering from Treatment Resistant Depression may one day find relief from the debilitating illness affecting their day to day lives.<\/p><p>If you think you may be suffering from depression please speak to your GP.<\/p><p>\u00a0<\/p><p><strong>Organisations who can help if you need someone to talk to:<\/strong><\/p><p><strong>Samaritans: Call 116 123 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>Shout 85258: text SHOUT to 85258 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>CALM: Call 0800 58 58 58 or use their webchat <a href=\"https:\/\/www.thecalmzone.net\/get-support#open-calmbot\">here<\/a>.\u00a0 The helpline and webchat are both open 5pm to midnight, 365 days a year.<\/strong><\/p><p>\u00a0<\/p>","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[55,9285,87,9280],"tags":[9252,9291,9248],"class_list":["post-31904","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-heart-and-vascular-disease","category-stem-cell-news","category-stem-cell-therapies","tag-blog","tag-heart-disease","tag-stem-cell-therapy"],"_links":{"self":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/31904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/comments?post=31904"}],"version-history":[{"count":8,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/31904\/revisions"}],"predecessor-version":[{"id":38769,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/31904\/revisions\/38769"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media\/31908"}],"wp:attachment":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media?parent=31904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/categories?post=31904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/tags?post=31904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}