{"id":32587,"date":"2024-04-21T12:39:38","date_gmt":"2024-04-21T12:39:38","guid":{"rendered":"https:\/\/cells4life.com\/?p=32587"},"modified":"2025-10-29T16:39:48","modified_gmt":"2025-10-29T16:39:48","slug":"umbilical-cord-stem-cells-for-crohns","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2024\/04\/umbilical-cord-stem-cells-for-crohns\/","title":{"rendered":"Researchers Investigate Use of Umbilical Cord Stem Cells for Crohn&#8217;s"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]\n<p class=\"ai-optimize-44\"><span style=\"font-weight: 400;\">A recent study published in the journal <em>eBioMedicine<\/em> found that umbilical cord stem cells may have the potential to heal the intestinal ulcers of patients suffering from Crohn\u2019s disease.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ai-optimize-45\"><span style=\"font-weight: 400;\">What is Crohn\u2019s disease?<\/span><\/h3>\n<p class=\"ai-optimize-46\"><span style=\"font-weight: 400;\">Crohn\u2019s disease is a condition that causes parts of the digestive system to become inflamed. Experts estimate that the disease affects more than three-quarters of a million people in the U.S., with symptoms including severe abdominal pain, diarrhea, tiredness and fatigue, appetite loss and in some cases, anemia. <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/9357-crohns-disease\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[1]<\/span><\/a> <a href=\"https:\/\/www.nhs.uk\/conditions\/crohns-disease\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2]<\/span><\/a><\/p>\n<p class=\"ai-optimize-47\"><span style=\"font-weight: 400;\">A lifelong condition, the root causes of Crohn\u2019s aren\u2019t yet known, but it\u2019s thought that there are several key factors that may contribute to the likelihood of developing the disease, such as:<\/span><\/p>\n<ul>\n<li class=\"ai-optimize-48\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Having had a particularly pernicious stomach bug<\/span><\/li>\n<li class=\"ai-optimize-49\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Whether any close relatives have Crohn\u2019s (genes)<\/span><\/li>\n<li class=\"ai-optimize-50\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If there\u2019s a preexisting immunological problem<\/span><\/li>\n<li class=\"ai-optimize-51\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If there\u2019s an imbalance in gut bacteria levels<\/span><\/li>\n<li class=\"ai-optimize-52\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Exposure to a range of environmental factors, including stress, smoking, taking certain medicines such as antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs).<\/span><\/li>\n<\/ul>\n<p class=\"ai-optimize-53\"><span style=\"font-weight: 400;\">Unfortunately, there are no cures available for Crohn\u2019s disease, with treatments limited to reducing the inflammation and severity of symptoms through medicinal, although this only has an efficacy rate of 40-60%, or surgical means which involves removing a portion of the digestive system. <\/span><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3]<\/span><\/a><\/p>\n<p class=\"ai-optimize-54\"><span style=\"font-weight: 400;\">With this in mind, the need to find a new approach to the treatment of Crohn\u2019s has a pressing urgency.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ai-optimize-55\"><span style=\"font-weight: 400;\">Exploring the application of umbilical cord stem cells for treating Crohn\u2019s disease<\/span><\/h3>\n<p class=\"ai-optimize-56\"><span style=\"font-weight: 400;\">Researchers conducted a pilot, open label clinical study between November 2020 to October 2023, with 17 patients with Crohn\u2019s disease.<\/span><\/p>\n<p class=\"ai-optimize-57\"><span style=\"font-weight: 400;\">The patients, who were aged between 18 to 75, were selected on the basis that they had moderate to severe Crohn\u2019s disease for at least three months prior to the start of the trial and that they had not responded to advanced treatment.<\/span><\/p>\n<p class=\"ai-optimize-58\"><span style=\"font-weight: 400;\">Patients received an injection of human umbilical cord mesenchymal stem cells (hUC-MSCs) both by colonoscopy and then by intravenous drip the following day. Patients were then monitored over the course of 24 weeks, with researchers measuring laboratory and clinical markers along with performing endoscopic assessments.<\/span><\/p>\n<p class=\"ai-optimize-59\"><span style=\"font-weight: 400;\">The researchers found that of the 17 patients, eight showed improvement in their SES-CD\u00a0 (Simple Endoscopic Score for Crohn\u2019s disease) scores, which measures the size and severity of ulcers wherein a higher score indicates a more severe disease, while 3 further patients also displayed mucosal healing, meaning their SES-CD scores became zero.<\/span><\/p>\n<p class=\"ai-optimize-60\"><span style=\"font-weight: 400;\">All patients achieved clinical remission by week 24 of the trial. <\/span><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4]<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ai-optimize-61\"><span style=\"font-weight: 400;\">How does the treatment work?<\/span><\/h3>\n<p class=\"ai-optimize-62\"><span style=\"font-weight: 400;\">During the course of the trial, the researchers were paying special attention to how the mesenchymal stem cells were working to provide such dramatic improvements in patient outcomes. In addition to showing the viability of the stem cell treatment, they also wanted to show how that treatment worked.<\/span><\/p>\n<p class=\"ai-optimize-63\"><span style=\"font-weight: 400;\">They did this by taking a biopsy of the mucosas at the margins of the intestinal lesions from 3 patients before and after the trial for transcriptome sequencing, a process that would allow them to access information about the gene regulation and protein content of cells.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-64\"><span style=\"font-weight: 400;\">The researchers\u2019 analysis revealed that the hUC-MSCs appeared to upregulate the expression of genes that maintain the integrity of the intestinal epithelial barrier &#8211; a mucus layer that regulates luminal contents (such as enzymes, food particles, bile and bacteria) and its interaction with the body\u2019s immune system &#8211; and downregulated the expression of genes relating to inflammatory response. <\/span><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5]<\/span><\/a><\/p>\n<p class=\"ai-optimize-65\"><span style=\"font-weight: 400;\">Essentially, what this suggests is that the application of stem cells led to the inhibition of the inflammatory response and an improvement in the integrity of the intestinal barrier, remedying two key aspects of intestinal function affected by Crohn\u2019s disease.<\/span><\/p>\n<p class=\"ai-optimize-66\"><span style=\"font-weight: 400;\">While there were limitations in the size and scope of this trial, what it showed was significant and promising potential for the effective application of umbilical cord stem cells in treating Crohn\u2019s disease, a huge step forward in making available a new avenue of treatment for those who live with the condition.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-67\"><span style=\"font-weight: 400;\">If you want to find out more about how you could give your baby access to their own umbilical cord and placental stem cells, sign up below for a free info kit.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"ai-optimize-68\"><b>References<\/b><\/p>\n<p class=\"ai-optimize-69\"><span style=\"font-weight: 400;\"><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/9357-crohns-disease\" target=\"_blank\" rel=\"noopener\">[1] Cleveland Clinic. (2023, December 4). <em data-start=\"100\" data-end=\"159\">Crohn\u2019s disease: What it is, symptoms, causes &amp; treatment<\/em>. Retrieved from<\/a> <a class=\"decorated-link\" href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/9357-crohns-disease?utm_source=chatgpt.com\" target=\"_new\" rel=\"noopener\" data-start=\"176\" data-end=\"242\">https:\/\/my.clevelandclinic.org\/health\/diseases\/9357-crohns-disease<\/a><\/span><\/p>\n<p class=\"ai-optimize-70\"><a href=\"https:\/\/www.nhs.uk\/conditions\/crohns-disease\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2] NHS England (2021, April 22). <\/span><i><span style=\"font-weight: 400;\">Overview: Crohn&#8217;s Disease<\/span><\/i><span style=\"font-weight: 400;\">. NHS. https:\/\/www.nhs.uk\/conditions\/crohns-disease\/<\/span><\/a><\/p>\n<p class=\"ai-optimize-71\"><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3] Qinjuan Sun et al., (2024) hUC-MSCs therapy for Crohn\u2019s disease: efficacy in TNBS-induced colitis in rats and a pilot clinical study, eBioMedicine, doi: https:\/\/doi.org\/10.1016\/j.ebiom.2024.105128. https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext<\/span><\/a><\/p>\n<p class=\"ai-optimize-72\"><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4] Qinjuan Sun et al., (2024) hUC-MSCs therapy for Crohn\u2019s disease: efficacy in TNBS-induced colitis in rats and a pilot clinical study, eBioMedicine, doi: https:\/\/doi.org\/10.1016\/j.ebiom.2024.105128. https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext<\/span><\/a><\/p>\n<p class=\"ai-optimize-73\"><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5] Qinjuan Sun et al., (2024) hUC-MSCs therapy for Crohn\u2019s disease: efficacy in TNBS-induced colitis in rats and a pilot clinical study, eBioMedicine, doi: https:\/\/doi.org\/10.1016\/j.ebiom.2024.105128. https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00163-4\/fulltext<\/span><\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;down-arrow&#8221; _builder_version=&#8221;4.27.4&#8243; background_color=&#8221;#bd144f&#8221; custom_padding=&#8221;0px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;RWP&#8221; module_id=&#8221;request-welcome-pack&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_layout=&#8221;dark&#8221; use_border_color=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]\n<h3>FIND OUT MORE, REQUEST YOUR FREE INFO KIT TODAY<\/h3>\n<p>All you need to know to make an informed decision.<\/p>\n<p>Provide your contact details to request:<\/p>\n<p>&#8211; Complete Info Kit and your Guide to Cord Blood Banking<br \/>&#8211; Information via 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wpcf7-hidden\" value=\"true\" type=\"hidden\" name=\"sugar_crm_lead\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"76dbb9e8-4c86-d341-0772-689602ea5afc\" type=\"hidden\" name=\"campaign_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"assigned_user_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"created_by\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"rwp\" type=\"hidden\" name=\"lead_source\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{EXT_REFERER}\" type=\"hidden\" name=\"webform_referrer_url_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{COOKIE:_#uid}\" type=\"hidden\" name=\"webform_contact_id_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"request-welcome-pack\" type=\"hidden\" name=\"originating_web_form_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{IP_ADDRESS}\" type=\"hidden\" name=\"webform_ip_address_c\" \/><input type='hidden' class='wpcf7-pum' value='{\"closepopup\":false,\"closedelay\":0,\"openpopup\":false,\"openpopup_id\":0}' \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>A recent study published in the journal eBioMedicine found that umbilical cord stem cells may have the potential to heal the intestinal ulcers of patients suffering from Crohn\u2019s disease. &nbsp; What is Crohn\u2019s disease? Crohn\u2019s disease is a condition that causes parts of the digestive system to become inflamed. Experts estimate that the disease affects [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":32589,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>Most people know what it\u2019s like to feel sadness. But when feeling down persists for weeks, or even months, it can be a sign of a mental health condition, like depression.<\/p><p>Although today people are well versed and more understanding of depression, some sufferers still find it difficult to find treatments.<\/p><h3>What is depression?<\/h3><p>Depression is a common mental health condition. It is characterised by low mood, feelings of hopelessness, losing interest in things which previously brought a sense of enjoyment, and feeling tearful.<\/p><p>Depression can also manifest in physical ways. Sleeping poorly, feeling tired, experiencing aches, pains, a diminished appetite, and decreased libido can all be impacts of depression. The symptoms range from mild to severe. In mild cases, a persistent low mood may be the cause, while severe cases may result in suicidal feelings or a desire to self harm <a href=\"https:\/\/www.nhs.uk\/mental-health\/conditions\/depression-in-adults\/overview\/\">[1]<\/a>.<\/p><p>Sometimes the causes of depression can be obvious, such as a bereavement or a traumatic event. Other times there might be no known cause, although family history could be the reason. Whatever the reason, once a person has identified they may be depressed, they should go and see their GP.<\/p><h3>What treatments are available?<\/h3><p>There are a plethora of treatments for depression that a doctor can prescribe, from talking therapies to pharmaceutical medications to exercise and more. Sometimes the GP may recommend one treatment or a combination of treatments but they will help support patients and signpost them to services which can bolster their support network.<\/p><p>The good news is that depression is among the most treatable mental health disorders.\u00a0 Between 80% and 90% percent of people with depression eventually respond well to treatment. Almost all patients gain some relief from their symptoms <a href=\"https:\/\/www.psychiatry.org\/patients-families\/depression\/what-is-depression#:~:text=Depression%20is%20among%20the%20most,some%20relief%20from%20their%20symptoms.\">[2]<\/a>.<\/p><h3>Treatment Resistant Depression<\/h3><p>For those with major depressive disorder, however, treatment can be harder to find. With up to one third of adults with the condition failing to respond to treatment, new avenues and treatments are being sought.<\/p><p>\u201cAlthough there is some disagreement as to how to define treatment-resistant depression, a patient is generally considered to have it if the individual hasn\u2019t responded to adequate doses of two different antidepressants taken for a sufficient duration of time, which is usually six weeks,\u201d explains Jaskaran Singh, M.D., Senior Director of Neuroscience, Janssen Pharmaceuticals <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[3]<\/a>.<\/p><p>The theory that depression may have causes currently unknown by scientists is one theory researchers are exploring to try and combat resistance to treatment.<\/p><p>\u201cOne of the more modern theories is that depression creates inflammation in the brain, or that inflammation in the brain creates depression. Traditional antidepressants only affect neurotransmitters, so this may be why some patients don\u2019t respond to them.\u201d\u00a0 says Alexander Papp, M.D., a psychiatrist at UC San Diego Health <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[4]<\/a>.<\/p><p>Whether or not this is the case, researchers are still trying to find solutions to Treatment Resistant Depression.<\/p><h3>The Potential of Cord Blood Therapy<\/h3><p>One study using umbilical cord blood cells delivered promising results. The study administered concentrated umbilical cord blood cells at a dose of 250 million cells via weekly injections over 4 weeks with 1 week intervals, to women who suffered with Treatment Resistant Depression.\u00a0 The results were tested against a control group who received a placebo.<\/p><p>The study found that the therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7087609\/\">[5]<\/a>. Other studies have also found that cellular therapies may have a role in combating Treatment Resistant Depression <a href=\"https:\/\/www.mdpi.com\/1999-4923\/15\/3\/814\">[6]<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8474995\/\">[7]<\/a>.<\/p><p>These studies give hope for finding new treatments. With the help of umbilical cord blood cells, those suffering from Treatment Resistant Depression may one day find relief from the debilitating illness affecting their day to day lives.<\/p><p>If you think you may be suffering from depression please speak to your GP.<\/p><p>\u00a0<\/p><p><strong>Organisations who can help if you need someone to talk to:<\/strong><\/p><p><strong>Samaritans: Call 116 123 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>Shout 85258: text SHOUT to 85258 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>CALM: Call 0800 58 58 58 or use their webchat <a href=\"https:\/\/www.thecalmzone.net\/get-support#open-calmbot\">here<\/a>.\u00a0 The helpline and webchat are both open 5pm to midnight, 365 days a year.<\/strong><\/p><p>\u00a0<\/p>","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[55,87,9280,76],"tags":[9252,9295,9248,9261,9296],"class_list":["post-32587","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-stem-cell-news","category-stem-cell-therapies","category-uses-for-cord-tissue","tag-blog","tag-crohns-disease","tag-stem-cell-therapy","tag-trial","tag-umbilical-cord-stem-cells"],"_links":{"self":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/32587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/comments?post=32587"}],"version-history":[{"count":9,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/32587\/revisions"}],"predecessor-version":[{"id":38731,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/32587\/revisions\/38731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media\/32589"}],"wp:attachment":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media?parent=32587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/categories?post=32587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/tags?post=32587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}