{"id":32686,"date":"2024-05-30T14:06:16","date_gmt":"2024-05-30T14:06:16","guid":{"rendered":"https:\/\/cells4life.com\/?p=32686"},"modified":"2025-10-29T15:33:36","modified_gmt":"2025-10-29T15:33:36","slug":"stem-cell-therapy-achieves-cure-for-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2024\/05\/stem-cell-therapy-achieves-cure-for-type-2-diabetes\/","title":{"rendered":"Stem Cell Therapy Achieves First-Ever Cure for Type 2 Diabetes"},"content":{"rendered":"[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]\n

Researchers in Shanghai have claimed to have achieved the world’s first successful cure for type 2 diabetes using stem cell-derived islet transplantation.<\/span><\/p>\n

Publishing their findings in the journal <\/span>Cell Discovery<\/span><\/a>, the team of scientists believe that this new therapy offers hope for the estimated 420 million people living with type 2 diabetes around the world. <\/span>[1]<\/span><\/a><\/p>\n

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What is type 2 diabetes?<\/span><\/h3>\n

Type 2 diabetes is a metabolic disorder that arises as a result of the body either being unable to produce insulin or being ineffective at using the insulin it produces in order to regulate blood sugar levels. <\/span>[2]<\/span><\/a>\u00a0<\/span><\/p>\n

Those with type 2 diabetes risk developing hyperglycemia, otherwise known as high blood glucose levels, as a result of being unable to metabolize glucose. Hyperglycemia can cause complications over time, including damage to organs.\u00a0\u00a0<\/span><\/p>\n

Current management strategies primarily involve glycemic control through medications including insulin, as well as strict diet management to monitor blood sugar levels, leaving a substantial unmet need for a definitive cure. <\/span>[3]<\/span><\/a><\/p>\n

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How did researchers develop the cure?<\/span><\/h3>\n

Scientists undertook a study centred around a 59-year-old male patient with a 25-year history of type 2 diabetes. Following a kidney transplant in 2017, the patient experienced a decline in pancreatic islet function, necessitating daily multi-dose insulin injections.\u00a0<\/span><\/p>\n

To address this challenge, the research team led by Dr. Yin Hao turned to a pioneering stem cell treatment. Utilizing the patient’s own endoderm stem cells (EnSCs), they were able to differentiate these stem cells into functional pancreatic islet cells – cells in the pancreas that secrete hormones, including insulin and glucagon, that help regulate blood sugar levels. <\/span>[4]<\/span><\/a><\/p>\n

Once differentiated, these so-called \u2018E-islet cells\u2019 could then be implanted into the patient. <\/span>[5]<\/span><\/a><\/p>\n

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What were the results of the transplant?<\/span><\/h3>\n

In July 2021, the patient underwent the autologous islet cell transplantation. Notably, the patient achieved insulin independence within a mere 11 weeks post-transplantation. Oral medication for diabetes management was gradually reduced and ultimately discontinued a year later.<\/span><\/p>\n

Follow-up examinations conducted over a prolonged period revealed restored pancreatic function, with the patient no longer requiring exogenous insulin or oral medications.\u00a0<\/span><\/p>\n

Additionally, normal kidney function was maintained, suggesting a potential long-term cure for both type 2 diabetes and the underlying complications associated with the initial kidney transplant. <\/span>[6]<\/span><\/a><\/p>\n

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What are the next steps in treating diabetes with stem cells?<\/span><\/h3>\n

This groundbreaking achievement signifies a paradigm shift in the treatment of type 2 diabetes.\u00a0<\/span><\/p>\n

The successful application of stem cell therapy offers a path towards a potential cure, paving the way for further research into the large-scale implementation and long-term efficacy of this novel approach.\u00a0<\/span><\/p>\n

While further clinical trials are warranted to validate these findings, this case study undoubtedly sparks hope for a future free from the burden of diabetes.<\/span><\/p>\n

If you want to learn more about saving stem cells for your baby, download your free Info Kit by filling out the form below.<\/span><\/p>\n

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References<\/b><\/p>\n

[1] <\/span>WHO (n.d.). <\/span>Diabetes<\/span><\/i>. World Health Organization. https:\/\/www.who.int\/health-topics\/diabetes#tab=tab_1<\/span><\/a><\/p>\n

[2] <\/span>Watts, M. (2023, December 14). <\/span>Type 2 Diabetes<\/span><\/i>. Diabetes.co.uk. <\/span><\/a>https:\/\/www.diabetes.co.uk\/type2-diabetes.html<\/span><\/a><\/p>\n

[3] Chong K, Chang JK-J, Chuang L-M.Recent advances in the treatment of type 2 diabetes mellitus using new drug therapies. Kaohsiung J Med Sci. 2024;40(3):212\u201320. <\/span><\/a>https:\/\/doi.org\/10.1002\/kjm2.12800<\/span><\/a><\/p>\n

[4] Wu, J., Li, T., Guo, M. et al. Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue. Cell Discov 10, 45 (2024). <\/span><\/a>https:\/\/doi.org\/10.1038\/s41421-024-00662-3<\/span><\/a><\/p>\n

[5] Da Silva Xavier, Gabriela. \u201cThe Cells of the Islets of Langerhans.\u201d Journal of clinical medicine vol. 7,3 54. 12 Mar. 2018, doi:10.3390\/jcm7030054<\/span><\/a><\/p>\n

[6] Wu, J., Li, T., Guo, M. et al. Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue. Cell Discov 10, 45 (2024). https:\/\/doi.org\/10.1038\/s41421-024-00662-3<\/span><\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”down-arrow” _builder_version=”4.27.4″ background_color=”#bd144f” custom_padding=”0px|||” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”RWP” module_id=”request-welcome-pack” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” use_border_color=”off” global_colors_info=”{}”]\n

FIND OUT MORE, REQUEST YOUR FREE INFO KIT TODAY<\/h3>\n

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