{"id":32755,"date":"2024-06-25T16:36:49","date_gmt":"2024-06-25T16:36:49","guid":{"rendered":"https:\/\/cells4life.com\/?p=32755"},"modified":"2025-10-27T15:16:13","modified_gmt":"2025-10-27T15:16:13","slug":"stem-cell-therapy-offers-hope-for-type-1-diabetes-cure","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2024\/06\/stem-cell-therapy-offers-hope-for-type-1-diabetes-cure\/","title":{"rendered":"Stem Cell Therapy Offers Hope for Type 1 Diabetes Cure"},"content":{"rendered":"[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]\n

The outcome of a recent clinical trial conducted by pharmaceutical company <\/span>Vertex <\/span><\/a>indicates huge promise for the development of a stem cell cure for type 1 diabetes.<\/span><\/p>\n

The phase 1\/2 study, whose results were presented at the <\/span>American Diabetes Association<\/span><\/a> 84th Scientific Sessions this month, found that the infusion of VX-880 – a new stem cell derived therapy – occasioned significant improvements in diabetic patients\u2019 wellbeing. <\/span>[1]<\/span><\/a>\u00a0<\/span><\/p>\n

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What is type 1 diabetes?\u00a0<\/span><\/h3>\n

Type 1 diabetes is an autoimmune condition that stops the pancreas producing insulin. Insulin is the hormone the body produces to move glucose (sugar) from the bloodstream into cells to make energy. Without insulin, glucose builds up in the bloodstream and leads to hyperglycemia. <\/span>[2]<\/span><\/a><\/p>\n

Complications from hyperglycemia can be severe, affecting major organs like the heart and kidneys. Glucose build up can also damage nerves, as well as the blood vessels in the eyes which can result in blindness. <\/span>[3]<\/span><\/a><\/p>\n

Those who have type 1 diabetes are required to take insulin every day, either with meals or at regular intervals, a process which can drastically alter lifestyle habits as well as quality of life. <\/span>[4]<\/span><\/a><\/p>\n

There is currently no known cure for type 1 diabetes and its root causes are unknown, although many believe the condition to be the result of either genetics or environmental factors like exposure to viruses.<\/span><\/p>\n

According to the American Diabetes Association, in 2021 around 2 million Americans had type 1 diabetes. <\/span>[5]<\/span><\/a><\/p>\n

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What were the results of the trial?<\/span><\/h3>\n

12 patients volunteered for the trial, all with type 1 diabetes and average hemoglobin A1C levels of 7.8%, a level that verges on risks from diabetic complications.<\/span><\/p>\n

A1C levels measure the amount of hemoglobin with attached glucose in the bloodstream. A higher percentage equates to a higher level of glucose. The average A1C level for a non-diabetic is below 5.7%. <\/span>[6]<\/span><\/a><\/p>\n

The 12 patients underwent an infusion of VX-880, a new therapy containing islet cells – cell clusters that produce insulin in the pancreas – derived from stem cells.<\/span><\/p>\n

Following the infusion, all patients demonstrated engraftment of the islet cells. By day 90, all patients also demonstrated glucose-responsive insulin production. All patients\u2019 A1C level also dropped below 7%.<\/span><\/p>\n

Out of 12 patients who received a full dose of VX-880, seven no longer needed daily insulin injections. Two more patients required about 70% less insulin to manage their blood sugar levels.<\/span><\/p>\n

These results are incredibly promising and the trial has since been expanded to include 37 patients as research into the effectiveness of VX-880 continues. <\/span>[7]<\/span><\/a><\/p>\n

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What is VX-880 stem cell therapy and how does it work?<\/span><\/h3>\n

VX-880 therapy involves introducing fresh islet cells derived from stem cells into the patient\u2019s body.\u00a0<\/span><\/p>\n

Because stem cells have the unique ability to differentiate into other specialized cells in the body, they can be reprogrammed to become a specific cell type that can then be used to replace or restore certain cells that may be missing through disease.\u00a0<\/span><\/p>\n

The stem cells used in the trial were allogeneic, meaning that they were sourced from a donor and required both a good match in addition to immunosuppressant drugs to prevent them from being rejected by the patients\u2019 immune systems.\u00a0<\/span><\/p>\n

The goal is for these new islet cells to restore the ability of the patients\u2019 pancreases to produce insulin, effectively curing the disease and drastically reducing the need for them to have to administer insulin exogenously. <\/span>[8]<\/span><\/a><\/p>\n

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Cord Blood Banking and Stem Cells<\/span><\/h3>\n

Breakthroughs like this underscore the incredible potential stem cells have in treating severe conditions like type 1 diabetes.\u00a0<\/span><\/p>\n

Though not yet an approved treatment, clinical trials like this one show that stem cells are at the forefront of developing regenerative therapies for diseases that are currently incurable.<\/span><\/p>\n

By banking your baby’s umbilical cord stem cells, you can ensure that they have them ready and waiting should they ever need to access one of these regenerative therapies in the future.\u00a0<\/span><\/p>\n

To find out more about saving stem cells for your baby, fill out the form below for a free Info Kit.<\/span><\/p>\n

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References<\/b><\/p>\n

[1] (2024, June 21). <\/span>Vertex Announces Positive Results From Ongoing Phase 1\/2 Study of VX-880 for the Treatment of Type 1 Diabetes Presented at the American Diabetes Association 84th Scientific Sessions<\/span><\/i>. Business Wire. https:\/\/www.businesswire.com\/news\/home\/20240621506971\/en\/Vertex-Announces-Positive-Results-From-Ongoing-Phase-12-Study-of-VX-880-for-the-Treatment-of-Type-1-Diabetes-Presented-at-the-American-Diabetes-Association-84th-Scientific-Sessions<\/span><\/a><\/p>\n

[2] Lucier J, Weinstock RS. Type 1 Diabetes. [Updated 2023 Mar 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507713\/<\/span><\/a><\/p>\n

[3] (2024, March 27). <\/span>Type 1 diabetes<\/span><\/i>. Mayo Clinic. https:\/\/www.mayoclinic.org\/diseases-conditions\/type-1-diabetes\/symptoms-causes\/syc-20353011<\/span><\/a><\/p>\n

[4] (2021, July 14). <\/span>What is type 1 diabetes<\/span><\/i>. NHS. https:\/\/www.nhs.uk\/conditions\/type-1-diabetes\/about-type-1-diabetes\/what-is-type-1-diabetes\/<\/span><\/a><\/p>\n

[5] American Diabetes Association. (2025, October 27). Statistics about diabetes<\/em>. https:\/\/diabetes.org\/about-diabetes\/statistics\/about-diabetes<\/a><\/span><\/i><\/a><\/p>\n

[6] <\/span>The A1C Test & Diabetes<\/span><\/i>. National Institute of Diabetes and Digestive and Kidney Diseases. https:\/\/www.niddk.nih.gov\/health-information\/diagnostic-tests\/a1c-test\/<\/span><\/a><\/p>\n

[7] (2024, June 21). <\/span>Vertex Announces Positive Results From Ongoing Phase 1\/2 Study of VX-880 for the Treatment of Type 1 Diabetes Presented at the American Diabetes Association 84th Scientific Sessions<\/span><\/i>. Business Wire. https:\/\/www.businesswire.com\/news\/home\/20240621506971\/en\/Vertex-Announces-Positive-Results-From-Ongoing-Phase-12-Study-of-VX-880-for-the-Treatment-of-Type-1-Diabetes-Presented-at-the-American-Diabetes-Association-84th-Scientific-Sessions<\/span><\/a><\/p>\n

[8] (2024, June 25). <\/span>Stem Cell Therapy Could Be Breakthrough Against Type 1 Diabetes<\/span><\/i>. U.S. News. https:\/\/www.usnews.com\/news\/health-news\/articles\/2024-06-25\/stem-cell-therapy-could-be-breakthrough-against-type-1-diabetes#:~:text=June%2025%2C%202024%2C%20at%206%3A00%20a.m.&text=TUESDAY%2C%20June%2025%2C%202024%20(,early%20clinical%20trial%20results%20show.<\/span><\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”down-arrow” _builder_version=”4.27.4″ background_color=”#bd144f” custom_padding=”0px|||” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”RWP” module_id=”request-welcome-pack” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” use_border_color=”off” global_colors_info=”{}”]\n

FIND OUT MORE, REQUEST YOUR FREE INFO KIT TODAY<\/h3>\n

All you need to know to make an informed decision.<\/p>\n

Provide your contact details to request:<\/p>\n

– Complete Info Kit and your Guide to Cord Blood Banking
– Information via email
– Contact from our specialist advisors<\/p>\n

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