{"id":32811,"date":"2024-07-11T16:43:52","date_gmt":"2024-07-11T16:43:52","guid":{"rendered":"https:\/\/cells4life.com\/?p=32811"},"modified":"2025-10-27T14:26:44","modified_gmt":"2025-10-27T14:26:44","slug":"promising-results-of-stem-cell-eczema-treatment","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2024\/07\/promising-results-of-stem-cell-eczema-treatment\/","title":{"rendered":"Promising Results of Stem Cell Eczema Treatment"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]\n<p class=\"ai-optimize-55\"><span style=\"font-weight: 400;\">The results from a new study into treating atopic dermatitis (AD) &#8211; the most common form of eczema &#8211; suggest that mesenchymal stem cells are effective in combating AD symptoms.<\/span><\/p>\n<p class=\"ai-optimize-56\"><span style=\"font-weight: 400;\">The phase 1\/2 trial, which aimed to treat patients suffering from moderate to severe AD symptoms, utilized human bone marrow-derived clonal mesenchymal stem cells (hcMSCs) which were delivered to patients via infusion.<\/span><\/p>\n<p class=\"ai-optimize-57\"><span style=\"font-weight: 400;\">Researchers believe that this treatment method is highly promising in improving symptoms of the chronic condition, which is estimated to affect approximately 2.6% of the population (204 million people) worldwide. <\/span><a href=\"https:\/\/academic.oup.com\/bjd\/article\/190\/1\/e6\/7485639\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[1]<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ai-optimize-58\"><span style=\"font-weight: 400;\">What is atopic dermatitis?<\/span><\/h3>\n<p class=\"ai-optimize-59\"><span style=\"font-weight: 400;\">Atopic dermatitis, also known as atopic eczema, is a condition that causes the skin to become dry, cracked, and itchy.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-60\"><span style=\"font-weight: 400;\">The most common form of eczema in children, atopic dermatitis is a long-term condition which can also arise for the first time during adulthood.<\/span><\/p>\n<p class=\"ai-optimize-61\"><span style=\"font-weight: 400;\">The exact causes of AD remain unknown, though it\u2019s thought that it may run in families.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-62\"><span style=\"font-weight: 400;\">Environmental factors such as the use of certain soaps and cleaning products, the weather, and stress have been shown to be triggers for AD flare-ups, and those who suffer from AD often also suffer from hay-fever and asthma.<\/span><\/p>\n<p class=\"ai-optimize-63\"><span style=\"font-weight: 400;\">Current treatment options for AD are limited, with the majority focusing on the alleviation or management of symptoms. Self-care practices, such as avoiding triggers and trying not to scratch, along with the use of moisturizers (emollients) and topical medicines are most commonly recommended to help combat AD symptoms. <\/span><a href=\"https:\/\/www.nhs.uk\/conditions\/atopic-eczema\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[2]<\/span><\/a><\/p>\n<p class=\"ai-optimize-64\"><span style=\"font-weight: 400;\">In many cases, AD often improves over time, but the current lack of effective treatment options, in addition to the widespread prevalence of the condition and its impact on sufferers\u2019 quality of life, means that finding new ways to combat AD is imperative.<\/span><\/p>\n<p class=\"ai-optimize-65\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h3 class=\"ai-optimize-66\"><span style=\"font-weight: 400;\">What did the new study find?<\/span><\/h3>\n<p class=\"ai-optimize-67\"><span style=\"font-weight: 400;\">The study was conducted in two phases.<\/span><\/p>\n<p class=\"ai-optimize-68\"><b>Phase 1<\/b><\/p>\n<ul>\n<li class=\"ai-optimize-69\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This phase saw 20 patients receive high and low doses of hcMSCs via infusions every two weeks.<\/span><\/li>\n<li class=\"ai-optimize-70\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Both high-dose and low-dose application was effective, with 67-70% of both groups displaying a 50% improvement in symptoms.\u00a0<\/span><\/li>\n<\/ul>\n<p class=\"ai-optimize-71\"><b>Phase 2<\/b><\/p>\n<p class=\"ai-optimize-72\"><span style=\"font-weight: 400;\">Phase 2 expanded to 72 patients, half of whom were given the low-dose, and the other half a placebo, with some interesting results:<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ul>\n<li class=\"ai-optimize-73\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">58% of patients who had the low-dose experienced over 50% improvement in symptoms compared to the placebo group, of which only 32% experienced a similar improvement.<\/span><\/li>\n<li class=\"ai-optimize-74\" style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Further yet, 24% of patients who had the low-dose even saw improvements of over 90% in their symptoms thanks to the treatment, compared to only 6% from the placebo group.<\/span><\/li>\n<\/ul>\n<p class=\"ai-optimize-75\"><span style=\"font-weight: 400;\">Overall, the results of the trial suggest that low doses of hcMSCs can dramatically improve symptoms of AD in sufferers whose condition is moderate to severe. <\/span><a href=\"https:\/\/www.dermatologytimes.com\/view\/promising-phase-1-2-trial-results-of-stem-cells-for-ad\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[3]<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ai-optimize-76\"><span style=\"font-weight: 400;\">How does the treatment work?\u00a0<\/span><\/h3>\n<p class=\"ai-optimize-77\"><span style=\"font-weight: 400;\">Mesenchymal stem cells have the ability to regulate the immune system. They interact with various immune cells and help reduce inflammation. Previous studies have shown these cells can lower inflammation in conditions like pancreatitis and improve symptoms in animal models of AD. <\/span><a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2024.06.013\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[4]<\/span><\/a> <a href=\"https:\/\/doi.org\/10.1053\/j.gastro.2023.02.009\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[5]<\/span><\/a> <a href=\"https:\/\/doi.org\/10.1038\/cddis.2014.299\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[6]<\/span><\/a> <a href=\"https:\/\/doi.org\/10.1038\/s41598-019-42964-7\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[7]<\/span><\/a><\/p>\n<p class=\"ai-optimize-78\"><span style=\"font-weight: 400;\">In this study, researchers hoped to build upon these previous findings by using mesenchymal stem cells derived from bone marrow in order to help with the immunomodulation necessary for improving AD symptoms.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ai-optimize-79\"><span style=\"font-weight: 400;\">What\u2019s next for the new AD treatment?<\/span><\/h3>\n<p class=\"ai-optimize-80\"><span style=\"font-weight: 400;\">While these results are promising, larger studies are needed to confirm the long-term benefits and safety of this treatment. However, this research opens up an exciting new avenue for eczema treatment that could significantly improve patients&#8217; quality of life.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ai-optimize-81\"><span style=\"font-weight: 400;\">Cord blood banking and mesenchymal stem cells<\/span><\/h3>\n<p class=\"ai-optimize-82\"><span style=\"font-weight: 400;\">The mesenchymal stem cells used in this study come from bone marrow, but they can also be found in a baby\u2019s umbilical cord.\u00a0<\/span><\/p>\n<p class=\"ai-optimize-83\"><span style=\"font-weight: 400;\">In 2017, a trial showed that mesenchymal stem cells from umbilical cord blood could effectively treat moderate to severe AD. <\/span><a href=\"https:\/\/doi.org\/10.1002\/stem.2401\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[8]<\/span><\/a><\/p>\n<p class=\"ai-optimize-84\"><span style=\"font-weight: 400;\">These mesenchymal stem cells can become various types of specialized cells, from muscle tissue to nerve cells, making them ideal for regenerative therapies.<\/span><\/p>\n<p class=\"ai-optimize-85\"><span style=\"font-weight: 400;\">By saving these stem cells at birth, you can provide your child with access to future advanced treatments.<\/span><\/p>\n<p class=\"ai-optimize-86\"><span style=\"font-weight: 400;\">To learn more, fill out the form below to receive a free Info Kit. This pack will explain how stem cell collection works, the benefits of storing stem cells, and current treatments using stem cells. It only takes a moment, but it could be the best decision you make for your child\u2019s future.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"ai-optimize-87\"><b>References<\/b><\/p>\n<p class=\"ai-optimize-88\"><a href=\"https:\/\/doi.org\/10.1093\/bjd\/ljad462\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[1] A study about how many people around the world have atopic dermatitis, British Journal of Dermatology, Volume 190, Issue 1, January 2024, Page e6, https:\/\/doi.org\/10.1093\/bjd\/ljad462<\/span><\/a><\/p>\n<p class=\"ai-optimize-89\"><a href=\"https:\/\/www.nhs.uk\/conditions\/atopic-eczema\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[2] (2023, November 11). <\/span><i><span style=\"font-weight: 400;\">Overview: Atopic eczema<\/span><\/i><span style=\"font-weight: 400;\">. NHS. https:\/\/www.nhs.uk\/conditions\/atopic-eczema\/<\/span><\/a><\/p>\n<p class=\"ai-optimize-90\"><a href=\"https:\/\/www.dermatologytimes.com\/view\/promising-phase-1-2-trial-results-of-stem-cells-for-ad\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[3] Hebebrand, M. (2024, July 8). <\/span><i><span style=\"font-weight: 400;\">Promising Phase 1\/2 Trial Results of Stem Cells for AD<\/span><\/i><span style=\"font-weight: 400;\">. Dermatology Times. https:\/\/www.dermatologytimes.com\/view\/promising-phase-1-2-trial-results-of-stem-cells-for-ad<\/span><\/a><\/p>\n<p class=\"ai-optimize-91\"><a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2024.06.013\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[4] Hyun-Min Seo, et al. Phase 1\/2 trials of human bone marrow\u2013derived clonal mesenchymal stem cells for treatment of adults with moderate to severe atopic dermatitis, Journal of Allergy and Clinical Immunology,2024,ISSN 0091-6749, https:\/\/doi.org\/10.1016\/j.jaci.2024.06.013. (<\/span><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0091674924006377\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0091674924006377<\/span><\/a><a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2024.06.013\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">)<\/span><\/a><\/p>\n<p class=\"ai-optimize-92\"><a href=\"https:\/\/doi.org\/10.1053\/j.gastro.2023.02.009\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[5] Il Sang Shin, et al., Human Bone Marrow\u2013derived Clonal Mesenchymal Stem Cells Decrease the Initial C-Reactive Protein Level in Patients With Moderately Severe to Severe Acute Pancreatitis, Gastroenterology, Volume 164, Issue 7, 2023, Pages 1317-1320.e2, ISSN 0016-5085, https:\/\/doi.org\/10.1053\/j.gastro.2023.02.009. (https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0016508523001439)<\/span><\/a><\/p>\n<p class=\"ai-optimize-93\"><a href=\"https:\/\/doi.org\/10.1038\/cddis.2014.299\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[6] Na, K., Yoo, H., Zhang, Y. et al. Bone marrow-derived clonal mesenchymal stem cells inhibit ovalbumin-induced atopic dermatitis. Cell Death Dis 5, e1345 (2014). https:\/\/doi.org\/10.1038\/cddis.2014.299<\/span><\/a><\/p>\n<p class=\"ai-optimize-94\"><a href=\"https:\/\/doi.org\/10.1038\/s41598-019-42964-7\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[7] Song, Jy., Kang, H.J., Ju, H.M. et al. Umbilical cord-derived mesenchymal stem cell extracts ameliorate atopic dermatitis in mice by reducing the T cell responses. Sci Rep 9, 6623 (2019). https:\/\/doi.org\/10.1038\/s41598-019-42964-7<\/span><\/a><\/p>\n<p class=\"ai-optimize-95\"><a href=\"https:\/\/doi.org\/10.1002\/stem.2401\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"font-weight: 400;\">[8] Hyung-Sik Kim, Ji Hyun Lee, Kyoung-Hwan Roh, Hee Jin Jun, Kyung-Sun Kang, Tae-Yoon Kim, Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I\/IIa Studies, Stem Cells, Volume 35, Issue 1, January 2017, Pages 248\u2013255, https:\/\/doi.org\/10.1002\/stem.2401<\/span><\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;down-arrow&#8221; _builder_version=&#8221;4.27.4&#8243; background_color=&#8221;#bd144f&#8221; custom_padding=&#8221;0px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;RWP&#8221; module_id=&#8221;request-welcome-pack&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_layout=&#8221;dark&#8221; use_border_color=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]\n<h3>FIND OUT MORE, REQUEST YOUR FREE INFO KIT TODAY<\/h3>\n<p>All you need to know to make an informed decision.<\/p>\n<p>Provide your contact details to request:<\/p>\n<p>&#8211; Complete Info Kit and your Guide to Cord Blood Banking<br \/>&#8211; Information via email<br \/>&#8211; Contact from our 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class=\"wpcf7-form-control-wrap\" data-name=\"welcome_pack_by_post_c\"><span class=\"wpcf7-form-control wpcf7-checkbox\"><span class=\"wpcf7-list-item first last\"><input type=\"checkbox\" name=\"welcome_pack_by_post_c[]\" value=\"Yes\" \/><span class=\"wpcf7-list-item-label\">Yes<\/span><\/span><\/span><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_street\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"Address 1\" value=\"\" type=\"text\" name=\"primary_address_street\" \/><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_city\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"Address 2\" value=\"\" type=\"text\" name=\"primary_address_city\" \/><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_state\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"State\" value=\"\" type=\"text\" name=\"primary_address_state\" \/><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_country\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"Country\" value=\"\" type=\"text\" name=\"primary_address_country\" \/><\/span>\n<\/p>\n<p><input class=\"wpcf7-form-control wpcf7-submit has-spinner wpcf7-button c4l-button-dark gtm-rwp-onpage\" type=\"submit\" value=\"REQUEST\" \/>\n<\/p>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"us\" type=\"hidden\" name=\"webform_site_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"true\" type=\"hidden\" name=\"sugar_crm_lead\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"76dbb9e8-4c86-d341-0772-689602ea5afc\" type=\"hidden\" name=\"campaign_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"assigned_user_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"created_by\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"rwp\" type=\"hidden\" name=\"lead_source\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{EXT_REFERER}\" type=\"hidden\" name=\"webform_referrer_url_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{COOKIE:_#uid}\" type=\"hidden\" name=\"webform_contact_id_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"request-welcome-pack\" type=\"hidden\" name=\"originating_web_form_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{IP_ADDRESS}\" type=\"hidden\" name=\"webform_ip_address_c\" \/><input type='hidden' class='wpcf7-pum' value='{\"closepopup\":false,\"closedelay\":0,\"openpopup\":false,\"openpopup_id\":0}' \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>The results from a new study into treating atopic dermatitis (AD) &#8211; the most common form of eczema &#8211; suggest that mesenchymal stem cells are effective in combating AD symptoms. The phase 1\/2 trial, which aimed to treat patients suffering from moderate to severe AD symptoms, utilized human bone marrow-derived clonal mesenchymal stem cells (hcMSCs) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":32816,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>Most people know what it\u2019s like to feel sadness. But when feeling down persists for weeks, or even months, it can be a sign of a mental health condition, like depression.<\/p><p>Although today people are well versed and more understanding of depression, some sufferers still find it difficult to find treatments.<\/p><h3>What is depression?<\/h3><p>Depression is a common mental health condition. It is characterised by low mood, feelings of hopelessness, losing interest in things which previously brought a sense of enjoyment, and feeling tearful.<\/p><p>Depression can also manifest in physical ways. Sleeping poorly, feeling tired, experiencing aches, pains, a diminished appetite, and decreased libido can all be impacts of depression. The symptoms range from mild to severe. In mild cases, a persistent low mood may be the cause, while severe cases may result in suicidal feelings or a desire to self harm <a href=\"https:\/\/www.nhs.uk\/mental-health\/conditions\/depression-in-adults\/overview\/\">[1]<\/a>.<\/p><p>Sometimes the causes of depression can be obvious, such as a bereavement or a traumatic event. Other times there might be no known cause, although family history could be the reason. Whatever the reason, once a person has identified they may be depressed, they should go and see their GP.<\/p><h3>What treatments are available?<\/h3><p>There are a plethora of treatments for depression that a doctor can prescribe, from talking therapies to pharmaceutical medications to exercise and more. Sometimes the GP may recommend one treatment or a combination of treatments but they will help support patients and signpost them to services which can bolster their support network.<\/p><p>The good news is that depression is among the most treatable mental health disorders.\u00a0 Between 80% and 90% percent of people with depression eventually respond well to treatment. Almost all patients gain some relief from their symptoms <a href=\"https:\/\/www.psychiatry.org\/patients-families\/depression\/what-is-depression#:~:text=Depression%20is%20among%20the%20most,some%20relief%20from%20their%20symptoms.\">[2]<\/a>.<\/p><h3>Treatment Resistant Depression<\/h3><p>For those with major depressive disorder, however, treatment can be harder to find. With up to one third of adults with the condition failing to respond to treatment, new avenues and treatments are being sought.<\/p><p>\u201cAlthough there is some disagreement as to how to define treatment-resistant depression, a patient is generally considered to have it if the individual hasn\u2019t responded to adequate doses of two different antidepressants taken for a sufficient duration of time, which is usually six weeks,\u201d explains Jaskaran Singh, M.D., Senior Director of Neuroscience, Janssen Pharmaceuticals <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[3]<\/a>.<\/p><p>The theory that depression may have causes currently unknown by scientists is one theory researchers are exploring to try and combat resistance to treatment.<\/p><p>\u201cOne of the more modern theories is that depression creates inflammation in the brain, or that inflammation in the brain creates depression. Traditional antidepressants only affect neurotransmitters, so this may be why some patients don\u2019t respond to them.\u201d\u00a0 says Alexander Papp, M.D., a psychiatrist at UC San Diego Health <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[4]<\/a>.<\/p><p>Whether or not this is the case, researchers are still trying to find solutions to Treatment Resistant Depression.<\/p><h3>The Potential of Cord Blood Therapy<\/h3><p>One study using umbilical cord blood cells delivered promising results. The study administered concentrated umbilical cord blood cells at a dose of 250 million cells via weekly injections over 4 weeks with 1 week intervals, to women who suffered with Treatment Resistant Depression.\u00a0 The results were tested against a control group who received a placebo.<\/p><p>The study found that the therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7087609\/\">[5]<\/a>. Other studies have also found that cellular therapies may have a role in combating Treatment Resistant Depression <a href=\"https:\/\/www.mdpi.com\/1999-4923\/15\/3\/814\">[6]<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8474995\/\">[7]<\/a>.<\/p><p>These studies give hope for finding new treatments. With the help of umbilical cord blood cells, those suffering from Treatment Resistant Depression may one day find relief from the debilitating illness affecting their day to day lives.<\/p><p>If you think you may be suffering from depression please speak to your GP.<\/p><p>\u00a0<\/p><p><strong>Organisations who can help if you need someone to talk to:<\/strong><\/p><p><strong>Samaritans: Call 116 123 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>Shout 85258: text SHOUT to 85258 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>CALM: Call 0800 58 58 58 or use their webchat <a href=\"https:\/\/www.thecalmzone.net\/get-support#open-calmbot\">here<\/a>.\u00a0 The helpline and webchat are both open 5pm to midnight, 365 days a year.<\/strong><\/p><p>\u00a0<\/p>","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[55,60,87,9280],"tags":[9252,9248,9261],"class_list":["post-32811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-news","category-stem-cell-news","category-stem-cell-therapies","tag-blog","tag-stem-cell-therapy","tag-trial"],"_links":{"self":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/32811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/comments?post=32811"}],"version-history":[{"count":11,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/32811\/revisions"}],"predecessor-version":[{"id":38700,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/32811\/revisions\/38700"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media\/32816"}],"wp:attachment":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media?parent=32811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/categories?post=32811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/tags?post=32811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}