{"id":38903,"date":"2025-11-27T12:24:20","date_gmt":"2025-11-27T12:24:20","guid":{"rendered":"https:\/\/cells4life.com\/us\/?p=38903"},"modified":"2025-12-30T12:47:50","modified_gmt":"2025-12-30T12:47:50","slug":"stem-cell-treatment-ischemic-stroke-consequences","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2025\/11\/stem-cell-treatment-ischemic-stroke-consequences\/","title":{"rendered":"Could Stem Cells Help Treat Ischemic Stroke Consequences?"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]\n<h3><span style=\"font-weight: 400;\">Key details<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\"><strong>Current treatment limitations:<\/strong> While ischemic strokes \u2013 which account for nearly 90% of all strokes \u2013 are currently treated with clot removal and supportive rehabilitation, there remains a significant unmet need for therapies that directly address neurological consequences.<\/li>\n<li style=\"font-weight: 400;\"><strong>Stem cell potential:<\/strong> Mesenchymal stem cells (MSCs), particularly those from the umbilical cord (UC-MSCs), are a key focus in regenerative medicine due to their ability to regulate the immune system, reduce inflammation, and aid tissue regeneration.<\/li>\n<li style=\"font-weight: 400;\"><strong>Treatment development:<\/strong> A recent Phase 2 randomized controlled trial demonstrated that UC-MSC treatment is safe, with patients showing improvements in neurological deficits, quality of life, and functional independence compared to a control group receiving only rehabilitation.<\/li>\n<li style=\"font-weight: 400;\"><strong>Administration route:<\/strong> The trial compared intravenous (IV) and intrathecal (IT) (spinal canal injection) delivery methods, finding that the IV group experienced fewer procedure-related adverse events and demonstrated statistically significant improvements in functional independence earlier (at 6 months) than the IT group.<\/li>\n<\/ul>\n<h3 style=\"font-weight: 400;\">What is an ischemic stroke?<\/h3>\n<p style=\"font-weight: 400;\">An ischemic stroke occurs when a clot cuts off blood flow to a part of the brain, preventing brain tissue from receiving oxygen and nutrients. This is a medical emergency, as strokes can happen suddenly and brain cells begin to die within minutes from a blockage happening.<a href=\"https:\/\/www.nhlbi.nih.gov\/health\/stroke\" target=\"_blank\" rel=\"noopener\">[1]<\/a><\/p>\n<p style=\"font-weight: 400;\">Stroke is a leading cause of death and disability worldwide<a href=\"https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates\" target=\"_blank\" rel=\"noopener\">[2]<\/a>, with ischemic strokes being the most common, accounting for just under 90% of all strokes.<a href=\"https:\/\/www.nhlbi.nih.gov\/health\/stroke\" target=\"_blank\" rel=\"noopener\">[1]<\/a><\/p>\n<p style=\"font-weight: 400;\">The consequences of stroke can be severe, and may include:<\/p>\n<ul>\n<li style=\"font-weight: 400;\">Paralysis<\/li>\n<li style=\"font-weight: 400;\">Sensory changes<\/li>\n<li style=\"font-weight: 400;\">Speech or language problems<\/li>\n<li style=\"font-weight: 400;\">Vision problems<\/li>\n<li style=\"font-weight: 400;\">Cognitive impairments and memory loss<\/li>\n<li style=\"font-weight: 400;\">Emotional and behavioral changes.<a href=\"https:\/\/www.stroke.org\/en\/about-stroke\/effects-of-stroke\" target=\"_blank\" rel=\"noopener\">[3]<\/a><\/li>\n<\/ul>\n<h3 style=\"font-weight: 400;\">What treatment is available for stroke and its consequences?<\/h3>\n<p style=\"font-weight: 400;\">Immediate treatment for ischemic stroke, provided the patient arrives at the hospital in time, can include:<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><strong>Thrombolysis:<\/strong> using a clot-dissolving medication to break up clots in the brain.<\/li>\n<li style=\"font-weight: 400;\"><strong>Thrombectomy:<\/strong> surgical removal of the clot using a clot retrieval device.<a href=\"https:\/\/www.stroke.org\/en\/about-stroke\/types-of-stroke\/ischemic-stroke-clots\" target=\"_blank\" rel=\"noopener\">[4]<\/a><a href=\"https:\/\/www.stroke.org.uk\/stroke\/types\/ischaemic\/treatments\" target=\"_blank\" rel=\"noopener\">[5]<\/a><\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">This is followed by treatment to reduce the risk of another stroke, such as blood-thinning medication and, potentially, surgery to remedy narrowed arteries.<a href=\"https:\/\/www.stroke.org.uk\/stroke\/types\/ischaemic\/treatments\" target=\"_blank\" rel=\"noopener\">[5]<\/a><\/p>\n<p style=\"font-weight: 400;\">Treatment for stroke complications is primarily supportive, and focuses on rehabilitation and recovery. Because each stroke is unique, this can vary widely, as it will focus on relearning lost skills and enabling as independent a life as possible. It can involve physiotherapy, speech and language therapy and occupational therapy.<a href=\"https:\/\/www.stroke.org\/en\/life-after-stroke\/stroke-rehab\/post-stroke-rehabilitation\" target=\"_blank\" rel=\"noopener\">[6]<\/a><a href=\"https:\/\/www.stroke.org.uk\/stroke\/recovery\" target=\"_blank\" rel=\"noopener\">[7]<\/a><a href=\"https:\/\/www.stroke.org\/-\/media\/Stroke-Files\/Stroke-Resource-Center\/Recovery\/Patient-Focused\/What-to-Expect-from-Stroke-Rehabilitation.pdf\" target=\"_blank\" rel=\"noopener\">[8]<\/a><\/p>\n<p style=\"font-weight: 400;\">In other words, recovery and rehabilitation treatment focuses on helping stroke patients adapt to their \u201cnew normal\u201d, whatever that may be, leaving a significant unmet need for a treatment that could directly address the neurological consequences of a stroke.<\/p>\n<h3><span style=\"font-weight: 400;\">How could stem cells help with the consequences of stroke?<\/span><\/h3>\n<p style=\"font-weight: 400;\">Mesenchymal stem cells (MSCs) are powerful cells which can be obtained from various sources, including bone marrow, adipose (fat) tissue, the umbilical cord and the placenta. These cells have the ability to self-renew and turn into other cell types, such as bone, fat, and cartilage; they can help regulate the body\u2019s immune system and reduce inflammation, promote the formation of new blood vessels, and can release molecules and growth factors which aid in tissue regeneration.<a href=\"https:\/\/link.springer.com\/article\/10.1186\/s13287-022-03054-0\" target=\"_blank\" rel=\"noopener\">[9]<\/a><\/p>\n<p style=\"font-weight: 400;\">These properties have made them a key focus of the regenerative medicine field, with numerous studies and clinical trials investigating their potential as a treatment for many illnesses and conditions which currently lack effective treatments or cures. MSCs derived from the umbilical cord (UC-MSCs), in particular, have shown in preclinical and clinical studies that they could serve as a safe and potentially effective treatment for the neurological deficits associated with ischemic stroke.<a href=\"https:\/\/academic.oup.com\/stcltm\/article\/14\/12\/szaf063\/8340972\" target=\"_blank\" rel=\"noopener\">[10]<\/a><\/p>\n<p style=\"font-weight: 400;\">In order to develop a treatment, researchers need to not only identify the best source of stem cells, but also the most appropriate dosage as well as the most effective administration method. It is in this context that a recent clinical trial comparing two different methods of administration places itself.<\/p>\n<h3><span style=\"font-weight: 400;\">What were the structure and findings of the clinical trial?<\/span><\/h3>\n<p style=\"font-weight: 400;\">The phase 2 randomized controlled trial evaluated the safety and efficacy of UC-MSCs delivered either via IV (into a vein) or intrathecally (into the spinal canal) for treating neurological deficits after ischemic stroke.<\/p>\n<p style=\"font-weight: 400;\">The study involved 32 patients aged 40\u201375 years who were in the subacute or chronic phase of stroke recovery (7 days to 24 months post-stroke):<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><strong>Patient groups:<\/strong> Patients were randomly assigned to receive UC-MSCs via IV or intrathecally (IT), in addition to standard rehabilitation therapy. A control group consisting of 16 more patients was created by matching patients one-to-one with those in the intrathecal group based on gender, age, and severity of stroke consequences as determined using the NIH stroke scale (NIHSS). This control group only received rehabilitation therapy.<\/li>\n<li style=\"font-weight: 400;\"><strong>Dosage:<\/strong> Patients in the treatment group received a dose of 1.5\u2009\u00d7\u200910<sup>6<\/sup> cells per kg of body weight at baseline, and then again 3 months after the first dose.<\/li>\n<li style=\"font-weight: 400;\"><strong>Rehabilitation:<\/strong> Standard rehabilitation therapy consisted of 30 sessions designed to improve cognitive ability, motor function, and overall quality of life, each lasting 60 minutes. The sessions were tailored to each patient and focused on physical, occupational and speech therapy.<\/li>\n<li style=\"font-weight: 400;\"><strong>Monitoring:<\/strong> All patients were followed for a year, with visits scheduled at baseline, 3 months, 6 months and a year.<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">The results:<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><strong>Safety:<\/strong> There were no severe adverse events related to the treatment. Overall, the adverse event rate was lower in the IV group than in the IT group, where patients experienced more procedure-related pain and headaches.<\/li>\n<li style=\"font-weight: 400;\"><strong>Improvements at 6 months:<\/strong> The IV group demonstrated statistically significant improvements in neurological deficits (NIHSS scores), functional independence, and quality of life compared to the control group. The IT group also showed an improvement compared to the control group, although not as significant.<\/li>\n<li><strong>Improvements at 12 months:<\/strong> Both the IV and IT groups showed statistically significant improvements compared to the control group. Researchers hypothesized that IT administration would be more effective than IV, but the study results did not support this assumption &#8211; there was no statistically significant difference between the two methods. Larger studies are needed to confirm the results and draw more accurate conclusions.<a href=\"https:\/\/academic.oup.com\/stcltm\/article\/14\/12\/szaf063\/8340972\" target=\"_blank\" rel=\"noopener\">[10]<\/a><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">What are the next steps?<\/span><\/h3>\n<p style=\"font-weight: 400;\">Future studies should focus on optimizing the dosage and frequency of the treatment, as well as determining whether any particular patient profile benefits especially well from the treatment. Larger-scale clinical trials will also be necessary to confirm the findings of any smaller-scale trial such as this one.<\/p>\n<p style=\"font-weight: 400;\">This research, as well as many other such trials investigating stem cell treatments, could come to fruition during your baby\u2019s lifetime. Having access to as many sources of stem cells as possible could be key for them to access such treatments, particularly for conditions such as stroke which can strike very suddenly. To learn more about how you could preserve a rich source of stem cells for your baby as soon as they are born, complete the form below to request our free info kit.<\/p>\n<h3 style=\"font-weight: 400;\">References<\/h3>\n<p><a href=\"https:\/\/www.nhlbi.nih.gov\/health\/stroke\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[1] National Heart, Lung and Blood Institute (2023). <i>What Is a Stroke?<\/i> https:\/\/www.nhlbi.nih.gov\/health\/stroke<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2] World Health Organization (2021).\u00a0<i>Mortality and global health estimates<\/i>. https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.stroke.org\/en\/about-stroke\/effects-of-stroke\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3] American Stroke Association (2025).\u00a0<i>Effects of stroke<\/i>. https:\/\/www.stroke.org\/en\/about-stroke\/effects-of-stroke<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.stroke.org\/en\/about-stroke\/types-of-stroke\/ischemic-stroke-clots\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4] American Stroke Association (2024).\u00a0<i>Ischemic Strokes (Clots)<\/i>. https:\/\/www.stroke.org\/en\/about-stroke\/types-of-stroke\/ischemic-stroke-clots<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.stroke.org.uk\/stroke\/types\/ischaemic\/treatments\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5] Stroke Association. (2024). <i>Ischaemic stroke treatments<\/i>. https:\/\/www.stroke.org.uk\/stroke\/types\/ischaemic\/treatments<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.stroke.org\/en\/life-after-stroke\/stroke-rehab\/post-stroke-rehabilitation\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[6] American Stroke Association (2024).\u00a0<i>Post-Stroke rehabilitation<\/i>. https:\/\/www.stroke.org\/en\/life-after-stroke\/stroke-rehab\/post-stroke-rehabilitation<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.stroke.org.uk\/stroke\/recovery\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[7] Stroke Association (2024). <i>Understanding recovery<\/i>. https:\/\/www.stroke.org.uk\/stroke\/recovery<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.stroke.org\/-\/media\/Stroke-Files\/Stroke-Resource-Center\/Recovery\/Patient-Focused\/What-to-Expect-from-Stroke-Rehabilitation.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[8] American Stroke Association. <i>What to Expect from Stroke Rehabilitation.<\/i> https:\/\/www.stroke.org\/-\/media\/Stroke-Files\/Stroke-Resource-Center\/Recovery\/Patient-Focused\/What-to-Expect-from-Stroke-Rehabilitation.pdf<\/span><\/a><\/p>\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s13287-022-03054-0\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[9] Margiana, R., et al. (2022). Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review. <i>Stem Cell Research &amp; Therapy<\/i>, 13(1). doi:https:\/\/doi.org\/10.1186\/s13287-022-03054-0<\/span><\/a><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/stcltm\/article\/14\/12\/szaf063\/8340972\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[10] Nguyen, L. T., et al. (2025). Intrathecal versus intravenous umbilical cord mesenchymal stem cells for ischemic stroke sequelae, <em>Stem Cells Translational Medicine<\/em>, Volume 14, Issue 12, December 2025, zaf063, https:\/\/doi.org\/10.1093\/stcltm\/szaf063<\/span><\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;down-arrow&#8221; _builder_version=&#8221;4.27.4&#8243; background_color=&#8221;#bd144f&#8221; custom_padding=&#8221;0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;RWP&#8221; module_id=&#8221;request-welcome-pack&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_layout=&#8221;dark&#8221; use_border_color=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]\n<h3>FIND OUT MORE, REQUEST YOUR FREE INFO KIT TODAY<\/h3>\n<p>All you need to know to make an informed decision.<\/p>\n<p>Provide your contact details to request:<\/p>\n<p>&#8211; Complete Info Kit and your Guide to Cord Blood Banking<br \/>&#8211; Information via email<br \/>&#8211; Contact from our specialist advisors<\/p>\n<p>&nbsp;<\/p>\n\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f14118-o1\" lang=\"en-US\" dir=\"ltr\" data-wpcf7-id=\"14118\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/us\/wp-json\/wp\/v2\/posts\/38903#wpcf7-f14118-o1\" method=\"post\" class=\"wpcf7-form init\" 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value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"created_by\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"rwp\" type=\"hidden\" name=\"lead_source\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{EXT_REFERER}\" type=\"hidden\" name=\"webform_referrer_url_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{COOKIE:_#uid}\" type=\"hidden\" name=\"webform_contact_id_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"request-welcome-pack\" type=\"hidden\" name=\"originating_web_form_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{IP_ADDRESS}\" type=\"hidden\" name=\"webform_ip_address_c\" \/><input type='hidden' class='wpcf7-pum' value='{\"closepopup\":false,\"closedelay\":0,\"openpopup\":false,\"openpopup_id\":0}' \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>Key details Current treatment limitations: While ischemic strokes \u2013 which account for nearly 90% of all strokes \u2013 are currently treated with clot removal and supportive rehabilitation, there remains a significant unmet need for therapies that directly address neurological consequences. Stem cell potential: Mesenchymal stem cells (MSCs), particularly those from the umbilical cord (UC-MSCs), are [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":38909,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>Most people know what it\u2019s like to feel sadness. But when feeling down persists for weeks, or even months, it can be a sign of a mental health condition, like depression.<\/p><p>Although today people are well versed and more understanding of depression, some sufferers still find it difficult to find treatments.<\/p><h3>What is depression?<\/h3><p>Depression is a common mental health condition. It is characterised by low mood, feelings of hopelessness, losing interest in things which previously brought a sense of enjoyment, and feeling tearful.<\/p><p>Depression can also manifest in physical ways. Sleeping poorly, feeling tired, experiencing aches, pains, a diminished appetite, and decreased libido can all be impacts of depression. The symptoms range from mild to severe. In mild cases, a persistent low mood may be the cause, while severe cases may result in suicidal feelings or a desire to self harm <a href=\"https:\/\/www.nhs.uk\/mental-health\/conditions\/depression-in-adults\/overview\/\">[1]<\/a>.<\/p><p>Sometimes the causes of depression can be obvious, such as a bereavement or a traumatic event. Other times there might be no known cause, although family history could be the reason. Whatever the reason, once a person has identified they may be depressed, they should go and see their GP.<\/p><h3>What treatments are available?<\/h3><p>There are a plethora of treatments for depression that a doctor can prescribe, from talking therapies to pharmaceutical medications to exercise and more. Sometimes the GP may recommend one treatment or a combination of treatments but they will help support patients and signpost them to services which can bolster their support network.<\/p><p>The good news is that depression is among the most treatable mental health disorders.\u00a0 Between 80% and 90% percent of people with depression eventually respond well to treatment. Almost all patients gain some relief from their symptoms <a href=\"https:\/\/www.psychiatry.org\/patients-families\/depression\/what-is-depression#:~:text=Depression%20is%20among%20the%20most,some%20relief%20from%20their%20symptoms.\">[2]<\/a>.<\/p><h3>Treatment Resistant Depression<\/h3><p>For those with major depressive disorder, however, treatment can be harder to find. With up to one third of adults with the condition failing to respond to treatment, new avenues and treatments are being sought.<\/p><p>\u201cAlthough there is some disagreement as to how to define treatment-resistant depression, a patient is generally considered to have it if the individual hasn\u2019t responded to adequate doses of two different antidepressants taken for a sufficient duration of time, which is usually six weeks,\u201d explains Jaskaran Singh, M.D., Senior Director of Neuroscience, Janssen Pharmaceuticals <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[3]<\/a>.<\/p><p>The theory that depression may have causes currently unknown by scientists is one theory researchers are exploring to try and combat resistance to treatment.<\/p><p>\u201cOne of the more modern theories is that depression creates inflammation in the brain, or that inflammation in the brain creates depression. Traditional antidepressants only affect neurotransmitters, so this may be why some patients don\u2019t respond to them.\u201d\u00a0 says Alexander Papp, M.D., a psychiatrist at UC San Diego Health <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[4]<\/a>.<\/p><p>Whether or not this is the case, researchers are still trying to find solutions to Treatment Resistant Depression.<\/p><h3>The Potential of Cord Blood Therapy<\/h3><p>One study using umbilical cord blood cells delivered promising results. The study administered concentrated umbilical cord blood cells at a dose of 250 million cells via weekly injections over 4 weeks with 1 week intervals, to women who suffered with Treatment Resistant Depression.\u00a0 The results were tested against a control group who received a placebo.<\/p><p>The study found that the therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7087609\/\">[5]<\/a>. Other studies have also found that cellular therapies may have a role in combating Treatment Resistant Depression <a href=\"https:\/\/www.mdpi.com\/1999-4923\/15\/3\/814\">[6]<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8474995\/\">[7]<\/a>.<\/p><p>These studies give hope for finding new treatments. With the help of umbilical cord blood cells, those suffering from Treatment Resistant Depression may one day find relief from the debilitating illness affecting their day to day lives.<\/p><p>If you think you may be suffering from depression please speak to your GP.<\/p><p>\u00a0<\/p><p><strong>Organisations who can help if you need someone to talk to:<\/strong><\/p><p><strong>Samaritans: Call 116 123 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>Shout 85258: text SHOUT to 85258 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>CALM: Call 0800 58 58 58 or use their webchat <a href=\"https:\/\/www.thecalmzone.net\/get-support#open-calmbot\">here<\/a>.\u00a0 The helpline and webchat are both open 5pm to midnight, 365 days a year.<\/strong><\/p><p>\u00a0<\/p>","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[55,9281,60,87,9280,76],"tags":[9252,9248],"class_list":["post-38903","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-neurological-disorders","category-news","category-stem-cell-news","category-stem-cell-therapies","category-uses-for-cord-tissue","tag-blog","tag-stem-cell-therapy"],"_links":{"self":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/38903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/comments?post=38903"}],"version-history":[{"count":5,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/38903\/revisions"}],"predecessor-version":[{"id":38912,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/38903\/revisions\/38912"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media\/38909"}],"wp:attachment":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media?parent=38903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/categories?post=38903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/tags?post=38903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}