{"id":39005,"date":"2026-01-28T10:17:17","date_gmt":"2026-01-28T10:17:17","guid":{"rendered":"https:\/\/cells4life.com\/us\/?p=39005"},"modified":"2026-04-08T16:01:13","modified_gmt":"2026-04-08T16:01:13","slug":"stem-cell-therapy-diabetic-foot-ulcers","status":"publish","type":"post","link":"https:\/\/cells4life.com\/us\/2026\/01\/stem-cell-therapy-diabetic-foot-ulcers\/","title":{"rendered":"Can Stem Cell Therapy Heal Diabetic Foot Ulcers?"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243; locked=&#8221;off&#8221;]\n<h3><span style=\"font-weight: 400;\">Key details<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\"><strong>High amputation risk:<\/strong> Diabetic foot ulcers are a serious complication of diabetes, often leading to infection and significantly higher amputation risks compared to the non-diabetic population.<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6852104\/\" target=\"_blank\" rel=\"noopener\">[1]<\/a><\/li>\n<li style=\"font-weight: 400;\"><strong>Treating the root cause:<\/strong> Stem cell therapies, particularly mesenchymal stem cells, are being investigated for their potential to support wound healing by promoting blood vessel formation, modulating inflammation, and influencing immune responses. These effects may help improve the local healing environment in diabetic foot ulcers.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38650719\/\" target=\"_blank\" rel=\"noopener\">[2]<\/a><\/li>\n<li style=\"font-weight: 400;\"><strong>Source matters:<\/strong> While bone marrow and adipose (fat) tissue are established sources of stem cells, umbilical cord\u2013derived mesenchymal stem cells (UC MSCs) are also widely studied because they can be collected non-invasively from tissue normally discarded at birth, such as umbilical cord tissue or cord blood. These neonatal cells have demonstrated a high capacity for proliferation and expansion in laboratory studies, making them a promising resource for research into future regenerative therapies. Clinical studies are ongoing to determine their safety, efficacy, and potential applications.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24772246\/\" target=\"_blank\" rel=\"noopener\">[3]<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41036706\/\" target=\"_blank\" rel=\"noopener\">[4]<\/a><\/li>\n<\/ul>\n<h3 style=\"font-weight: 400;\">What are diabetic foot ulcers and why are they dangerous?<\/h3>\n<p style=\"font-weight: 400;\">Diabetic foot ulcers are chronic wounds caused by a combination of nerve damage (neuropathy) and restricted blood supply, which can lead to severe infection and tissue death.<\/p>\n<p style=\"font-weight: 400;\">Because diabetic neuropathy causes loss of sensation in the legs and feet, small nicks and wounds frequently go unnoticed and untreated, leading them to ulcerate or become infected. Simultaneously, damage to blood vessels restricts the blood supply, meaning the feet receive fewer infection-fighting cells, causing wounds to heal slowly and potentially become gangrenous.<a href=\"https:\/\/www.diabetes.org.uk\/sites\/default\/files\/migration\/pdf\/footcare-for-people-with-diabetes.pdf\" target=\"_blank\" rel=\"noopener\">[5]<\/a><a href=\"https:\/\/www.nhs.uk\/conditions\/peripheral-neuropathy\/complications\/\" target=\"_blank\" rel=\"noopener\">[6]<\/a><\/p>\n<p style=\"font-weight: 400;\">The statistics regarding this condition:<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><strong>Prevalence:<\/strong> Up to one third of people with diabetes will develop a foot ulcer during their lifetime.<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9791571\/\" target=\"_blank\" rel=\"noopener\">[7]<\/a><\/li>\n<li style=\"font-weight: 400;\"><strong>Amputation risk:<\/strong> The risk of leg, foot, or toe amputation for people with diabetes is more than 20 times that of people without diabetes. Up to 28% of diabetic foot ulcers could result in some form of amputation.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36054820\/\" target=\"_blank\" rel=\"noopener\">[8]<\/a><\/li>\n<li style=\"font-weight: 400;\"><strong>Mortality:<\/strong> People who develop diabetic foot ulcers or require amputation often have other serious health conditions, and overall survival can be reduced. Studies suggest that around 35\u201350% of patients may die within five years of developing a foot ulcer, with higher risks in those who require amputation. Outcomes vary depending on overall health, ulcer severity, and access to care.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36054820\/\" target=\"_blank\" rel=\"noopener\">[8]<\/a><\/li>\n<\/ul>\n<h3 style=\"font-weight: 400;\">How are diabetic foot ulcers currently treated?<\/h3>\n<p style=\"font-weight: 400;\">Current treatment for diabetic foot ulcers focuses mainly on symptom management, involving wound care, offloading pressure, and infection control.<\/p>\n<p style=\"font-weight: 400;\">Standard protocols include dressings, antibiotics, compression clothes, and keeping weight off the foot using orthotics, special footwear, or wheelchairs. More invasive treatment, including debridement (surgical removal of infected tissue), may also be necessary.<a href=\"https:\/\/www.england.nhs.uk\/north-east-yorkshire\/wp-content\/uploads\/sites\/49\/2019\/07\/foot-ulcer-information-guide.pdf\" target=\"_blank\" rel=\"noopener\">[9]<\/a><\/p>\n<p style=\"font-weight: 400;\">However, these therapies often fail to achieve complete healing. Only two thirds of diabetic foot ulcers eventually heal without surgery.<a href=\"https:\/\/www.diabetes.org.uk\/sites\/default\/files\/migration\/pdf\/footcare-for-people-with-diabetes.pdf\" target=\"_blank\" rel=\"noopener\">[5]<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9791571\/\" target=\"_blank\" rel=\"noopener\">[7]<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36054820\/\" target=\"_blank\" rel=\"noopener\">[8]<\/a><\/p>\n<h3><span style=\"font-weight: 400;\">How could stem cell therapy help heal diabetic ulcers?<\/span><\/h3>\n<p style=\"font-weight: 400;\">Therapies based on mesenchymal stem cells (MSCs) have emerged as a promising strategy for addressing the underlying pathophysiology of diabetic foot ulcers (DFUs). MSCs exert multifactorial effects, including immunomodulation, anti-inflammatory activity, angiogenic promotion, and recruitment of reparative immune cells to the site of injury. These properties collectively target the principal contributors to impaired healing in DFUs, namely, chronic inflammation, abnormal immune responses, and inadequate microvascular perfusion, mechanisms that conventional therapies often fail to correct.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38650719\/\" target=\"_blank\" rel=\"noopener\">[2]<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37008908\/\" target=\"_blank\" rel=\"noopener\">[10]<\/a><\/p>\n<p style=\"font-weight: 400;\">Preclinical and clinical investigations have explored the therapeutic potential of MSCs in DFUs, demonstrating encouraging outcomes. A 2022 meta-analysis, aggregating data from 14 studies, reported that stem cell therapies significantly outperformed standard care across several critical endpoints:<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9375292\/\" target=\"_blank\" rel=\"noopener\">[11]<\/a><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><strong>Enhanced wound healing:<\/strong> Higher rates of ulcer closure and improved local blood flow.<\/li>\n<li style=\"font-weight: 400;\"><strong>Pain amelioration:<\/strong> Increased pain-free walking distance and reduced pain at rest.<\/li>\n<li style=\"font-weight: 400;\"><strong>Limb preservation:<\/strong> A notable reduction in lower-limb amputation rates.<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">These findings suggest that MSC-based therapies offer a mechanistically rational and clinically beneficial approach to DFU management, addressing not only symptomatic healing but also the underlying biological deficiencies that drive chronic, non-healing wounds.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38650719\/\" target=\"_blank\" rel=\"noopener\">[2]<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37008908\/\" target=\"_blank\" rel=\"noopener\">[10]<\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9375292\/\" target=\"_blank\" rel=\"noopener\">[11]<\/a><\/p>\n<h3><span style=\"font-weight: 400;\">What challenges remain for widespread clinical use?<\/span><\/h3>\n<p style=\"font-weight: 400;\">Despite encouraging results, challenges such as patient variability and the need for standardized data prevent the treatment from being ready for widespread use immediately.<\/p>\n<p style=\"font-weight: 400;\">Small differences between patients, their age, how well their diabetes is controlled, vascular disease, and the microorganisms inhabiting the ulcer, can have an impact on how the treatment works. This makes it complicated to assemble a single set of coherent, standardized data from multiple small-scale trials. Thus, larger-scale trials with a lengthy follow-up period will be required to ensure the treatment is effective and remains so long-term.<a href=\"https:\/\/www.dovepress.com\/advances-in-stem-cell-therapy-for-diabetic-foot-ulcers-peer-reviewed-fulltext-article-DMSO\" target=\"_blank\" rel=\"noopener\">[12]<\/a><\/p>\n<h3><span style=\"font-weight: 400;\">Which types of stem cells could be effective for treating diabetic foot ulcers?<\/span><\/h3>\n<p style=\"font-weight: 400;\">Research currently focuses on Mesenchymal Stem Cells (MSCs) derived from bone marrow, adipose (fat) tissue, or umbilical cord blood, though each source presents different advantages and challenges.<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><strong>Bone Marrow MSCs:<\/strong> They have an established clinical track record and show strong potential for vascular regeneration. However, they require invasive collection procedures. Furthermore, their regenerative potential may be impaired by the donor&#8217;s age, as well as, in the case of autologous (using the patient\u2019s own cells) therapies, by abnormal bone marrow microenvironment caused by diabetes.<\/li>\n<li style=\"font-weight: 400;\"><strong>Adipose (Fat) MSCs:<\/strong> They are easy to collect and expand\u00a0<em>in vitro<\/em>. Research has found that they can promote wound healing, reduce inflammation, and improve tissue regeneration. However, their function may be compromised by the patient\u2019s weight and diabetes-related lipotoxicity (fat accumulation in organs) can also reduce these cells\u2019 ability to migrate to the wound site.<\/li>\n<li style=\"font-weight: 400;\"><strong>Umbilical Cord MSCs:<\/strong> These cells have high self-renewal abilities, strong immunoregulatory functions, and can promote angiogenesis and reduce infection risk.<a href=\"https:\/\/www.dovepress.com\/advances-in-stem-cell-therapy-for-diabetic-foot-ulcers-peer-reviewed-fulltext-article-DMSO\" target=\"_blank\" rel=\"noopener\">[12]<\/a> However, access to them is limited by the fact that they can only be collected immediately after birth.<\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">How can parents prepare for the potential of future stem cell treatments?<\/span><\/h3>\n<p style=\"font-weight: 400;\">Research is ongoing into the use of stem cells, including those from umbilical cord blood, for a variety of conditions, such as diabetic complications. If parents choose to collect and store their baby\u2019s cord blood at birth, these cells could be available for future research or potential treatments.<\/p>\n<p style=\"font-weight: 400;\">For parents who want to learn more about cord blood collection and storage, our free info kit explains the process and options.<\/p>\n<h3 style=\"font-weight: 400;\">References<\/h3>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6852104\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[1] Paisey, R. B., Abbott, A., Paisey, C. F., Walker, D., Birch, R., Bowen, B., \u2026 Darke, S. (2019). Diabetic foot ulcer incidence and survival with improved diabetic foot services: An 18-year study. Diabetic Medicine, 36(11), 1424\u20131430]<\/span><\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38650719\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[2] Hetta HF, Elsaghir A, Sijercic VC, Akhtar MS, Gad SA, Moses A, Zeleke MS, Alanazi FE, Ahmed AK, Ramadan YN. Mesenchymal stem cell therapy in diabetic foot ulcer: An updated comprehensive review. Health Sci Rep. 2024 Apr 21;7(4):e2036. doi: 10.1002\/hsr2.2036. PMID: 38650719; PMCID: PMC11033295.<\/span><\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24772246\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[3] Nagamura-Inoue T, He H. Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility. World J Stem Cells. 2014 Apr 26;6(2):195-202. doi: 10.4252\/wjsc.v6.i2.195. PMID: 24772246; PMCID: PMC3999777<\/span><\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41036706\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[4] Hussein M. Advancing regenerative therapies with umbilical cord-derived mesenchymal stem cells: A review. Biomol Biomed. 2025 Oct 1;26(4):537-546. doi: 10.17305\/bb.2025.13147. PMID: 41036706; PMCID: PMC12710621.<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.diabetes.org.uk\/sites\/default\/files\/migration\/pdf\/footcare-for-people-with-diabetes.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[5] Kerr, M. (2012). <i>Foot Care for People with Diabetes: The Economic Case for Change<\/i>. https:\/\/www.diabetes.org.uk\/sites\/default\/files\/migration\/pdf\/footcare-for-people-with-diabetes.pdf<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.nhs.uk\/conditions\/peripheral-neuropathy\/complications\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[6] NHS (2022). <i>Complications &#8211; Peripheral neuropathy<\/i>. https:\/\/www.nhs.uk\/conditions\/peripheral-neuropathy\/complications\/<\/span><\/a><\/p>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9791571\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[7] Akkus, G. and Sert, M. (2022). Diabetic foot ulcers: A devastating complication of diabetes mellitus continues non-stop in spite of new medical treatment modalities. <i>World Journal of Diabetes<\/i>, 13(12), pp.1106\u20131121. doi:https:\/\/doi.org\/10.4239\/wjd.v13.i12.1106<\/span><\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36054820\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[8] Chen L, Sun S, Gao Y, Ran X. Global mortality of diabetic foot ulcer: A systematic review and meta-analysis of observational studies. Diabetes Obes Metab. 2023 Jan;25(1):36-45. doi: 10.1111\/dom.14840. Epub 2022 Sep 4. PMID: 36054820.<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.england.nhs.uk\/north-east-yorkshire\/wp-content\/uploads\/sites\/49\/2019\/07\/foot-ulcer-information-guide.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[9] NHS Northern England. <em>Diabetes &#8211; Foot Ulcers<\/em>. https:\/\/www.england.nhs.uk\/north-east-yorkshire\/wp-content\/uploads\/sites\/49\/2019\/07\/foot-ulcer-information-guide.pdf<\/span><\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37008908\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[10] Yu X, Liu P, Li Z, Zhang Z. Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds. Front Endocrinol (Lausanne). 2023 Mar 16;14:1099310. doi: 10.3389\/fendo.2023.1099310. PMID: 37008908; PMCID: PMC10061144.<\/span><\/a><\/p>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9375292\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[11] Sun, Y., Zhao, J., Zhang, L., Li, Z. and Lei, S. (2022). Effectiveness and safety of stem cell therapy for diabetic foot: a meta-analysis update. <i>Stem Cell Research &amp; Therapy<\/i>, 13(1). doi:https:\/\/doi.org\/10.1186\/s13287-022-03110-9<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.dovepress.com\/advances-in-stem-cell-therapy-for-diabetic-foot-ulcers-peer-reviewed-fulltext-article-DMSO\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">[12] Wang, B., Zhao, G., Zhang, J., Chen, W., Yang, S. and Sun, Y. (2025). Advances in Stem Cell Therapy for Diabetic Foot Ulcers. <i>Diabetes, Metabolic Syndrome and Obesity<\/i>, Volume 18, pp.4021\u20134034. doi:https:\/\/doi.org\/10.2147\/dmso.s564011<\/span><\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;down-arrow&#8221; _builder_version=&#8221;4.27.4&#8243; background_color=&#8221;#bd144f&#8221; custom_padding=&#8221;0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;RWP&#8221; module_id=&#8221;request-welcome-pack&#8221; _builder_version=&#8221;4.27.4&#8243; 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value=\"09\">09<\/option><option value=\"10\">10<\/option><option value=\"11\">11<\/option><option value=\"12\">12<\/option><option value=\"13\">13<\/option><option value=\"14\">14<\/option><option value=\"15\">15<\/option><option value=\"16\">16<\/option><option value=\"17\">17<\/option><option value=\"18\">18<\/option><option value=\"19\">19<\/option><option value=\"20\">20<\/option><option value=\"21\">21<\/option><option value=\"22\">22<\/option><option value=\"23\">23<\/option><option value=\"24\">24<\/option><option value=\"25\">25<\/option><option value=\"26\">26<\/option><option value=\"27\">27<\/option><option value=\"28\">28<\/option><option value=\"29\">29<\/option><option value=\"30\">30<\/option><option value=\"31\">31<\/option><\/select><\/span><span class=\"wpcf7-form-control-wrap\" data-name=\"delivery_year\"><select class=\"wpcf7-form-control wpcf7-select wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" name=\"delivery_year\"><option value=\"\">Year<\/option><option value=\"2026\">2026<\/option><option value=\"2027\">2027<\/option><\/select><\/span><\/span>\n<\/p>\n<p><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_postalcode\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-uppercase\" aria-invalid=\"false\" placeholder=\"Zip Code\" value=\"\" type=\"text\" name=\"primary_address_postalcode\" \/><\/span>\n<\/p>\n<p id=\"cf7tosugar_by_post\">By mail?<span class=\"wpcf7-form-control-wrap\" data-name=\"welcome_pack_by_post_c\"><span class=\"wpcf7-form-control wpcf7-checkbox\"><span class=\"wpcf7-list-item first last\"><input type=\"checkbox\" name=\"welcome_pack_by_post_c[]\" value=\"Yes\" \/><span class=\"wpcf7-list-item-label\">Yes<\/span><\/span><\/span><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_street\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"Address 1\" value=\"\" type=\"text\" name=\"primary_address_street\" \/><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_city\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"Address 2\" value=\"\" type=\"text\" name=\"primary_address_city\" \/><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_state\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"State\" value=\"\" type=\"text\" name=\"primary_address_state\" \/><\/span>\n<\/p>\n<p class=\"cf7tosugar_address\"><span class=\"wpcf7-form-control-wrap\" data-name=\"primary_address_country\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text c4l-capitalize\" aria-invalid=\"false\" placeholder=\"Country\" value=\"\" type=\"text\" name=\"primary_address_country\" \/><\/span>\n<\/p>\n<p><input class=\"wpcf7-form-control wpcf7-submit has-spinner wpcf7-button c4l-button-dark gtm-rwp-onpage\" type=\"submit\" value=\"REQUEST\" \/>\n<\/p>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"us\" type=\"hidden\" name=\"webform_site_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"true\" type=\"hidden\" name=\"sugar_crm_lead\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"76dbb9e8-4c86-d341-0772-689602ea5afc\" type=\"hidden\" name=\"campaign_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"assigned_user_id\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"e4987368-af56-291e-0908-4e82dbf541c4\" type=\"hidden\" name=\"created_by\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"rwp\" type=\"hidden\" name=\"lead_source\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{EXT_REFERER}\" type=\"hidden\" name=\"webform_referrer_url_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{COOKIE:_#uid}\" type=\"hidden\" name=\"webform_contact_id_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"request-welcome-pack\" type=\"hidden\" name=\"originating_web_form_c\" \/>\n<input class=\"wpcf7-form-control wpcf7-hidden\" value=\"{IP_ADDRESS}\" type=\"hidden\" name=\"webform_ip_address_c\" \/><input type='hidden' class='wpcf7-pum' value='{\"closepopup\":false,\"closedelay\":0,\"openpopup\":false,\"openpopup_id\":0}' \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;LAM bio block&#8221; module_class=&#8221;down-arrow&#8221; _builder_version=&#8221;4.27.5&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_team_member name=&#8221;Lesley-Ann Martin, PhD&#8221; position=&#8221;Chief Scientific Officer at Cells4Life&#8221; image_url=&#8221;https:\/\/cells4life.com\/wp-content\/uploads\/2019\/08\/lesley-ann.png&#8221; admin_label=&#8221;Person&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_css_free_form=&#8221;selector {||  background: #e3f2f8;||  border-radius: 30px;||  padding: 20px;||}||selector img {||  height: 100px;||  width: 100px;||}&#8221; global_colors_info=&#8221;{}&#8221;]\n<p style=\"font-weight: 400;\">Dr. Martin holds a PhD in Molecular Biology from the University of Reading and has extensive research experience at the Institute of Cancer Research. She oversees all scientific and laboratory operations at Cells4Life.<\/p>\n[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>Key details High amputation risk: Diabetic foot ulcers are a serious complication of diabetes, often leading to infection and significantly higher amputation risks compared to the non-diabetic population.[1] Treating the root cause: Stem cell therapies, particularly mesenchymal stem cells, are being investigated for their potential to support wound healing by promoting blood vessel formation, modulating [&hellip;]<\/p>\n","protected":false},"author":1447,"featured_media":39006,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>Most people know what it\u2019s like to feel sadness. But when feeling down persists for weeks, or even months, it can be a sign of a mental health condition, like depression.<\/p><p>Although today people are well versed and more understanding of depression, some sufferers still find it difficult to find treatments.<\/p><h3>What is depression?<\/h3><p>Depression is a common mental health condition. It is characterised by low mood, feelings of hopelessness, losing interest in things which previously brought a sense of enjoyment, and feeling tearful.<\/p><p>Depression can also manifest in physical ways. Sleeping poorly, feeling tired, experiencing aches, pains, a diminished appetite, and decreased libido can all be impacts of depression. The symptoms range from mild to severe. In mild cases, a persistent low mood may be the cause, while severe cases may result in suicidal feelings or a desire to self harm <a href=\"https:\/\/www.nhs.uk\/mental-health\/conditions\/depression-in-adults\/overview\/\">[1]<\/a>.<\/p><p>Sometimes the causes of depression can be obvious, such as a bereavement or a traumatic event. Other times there might be no known cause, although family history could be the reason. Whatever the reason, once a person has identified they may be depressed, they should go and see their GP.<\/p><h3>What treatments are available?<\/h3><p>There are a plethora of treatments for depression that a doctor can prescribe, from talking therapies to pharmaceutical medications to exercise and more. Sometimes the GP may recommend one treatment or a combination of treatments but they will help support patients and signpost them to services which can bolster their support network.<\/p><p>The good news is that depression is among the most treatable mental health disorders.\u00a0 Between 80% and 90% percent of people with depression eventually respond well to treatment. Almost all patients gain some relief from their symptoms <a href=\"https:\/\/www.psychiatry.org\/patients-families\/depression\/what-is-depression#:~:text=Depression%20is%20among%20the%20most,some%20relief%20from%20their%20symptoms.\">[2]<\/a>.<\/p><h3>Treatment Resistant Depression<\/h3><p>For those with major depressive disorder, however, treatment can be harder to find. With up to one third of adults with the condition failing to respond to treatment, new avenues and treatments are being sought.<\/p><p>\u201cAlthough there is some disagreement as to how to define treatment-resistant depression, a patient is generally considered to have it if the individual hasn\u2019t responded to adequate doses of two different antidepressants taken for a sufficient duration of time, which is usually six weeks,\u201d explains Jaskaran Singh, M.D., Senior Director of Neuroscience, Janssen Pharmaceuticals <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[3]<\/a>.<\/p><p>The theory that depression may have causes currently unknown by scientists is one theory researchers are exploring to try and combat resistance to treatment.<\/p><p>\u201cOne of the more modern theories is that depression creates inflammation in the brain, or that inflammation in the brain creates depression. Traditional antidepressants only affect neurotransmitters, so this may be why some patients don\u2019t respond to them.\u201d\u00a0 says Alexander Papp, M.D., a psychiatrist at UC San Diego Health <a href=\"https:\/\/www.jnj.com\/health-and-wellness\/4-facts-about-treatment-resistant-depression\">[4]<\/a>.<\/p><p>Whether or not this is the case, researchers are still trying to find solutions to Treatment Resistant Depression.<\/p><h3>The Potential of Cord Blood Therapy<\/h3><p>One study using umbilical cord blood cells delivered promising results. The study administered concentrated umbilical cord blood cells at a dose of 250 million cells via weekly injections over 4 weeks with 1 week intervals, to women who suffered with Treatment Resistant Depression.\u00a0 The results were tested against a control group who received a placebo.<\/p><p>The study found that the therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7087609\/\">[5]<\/a>. Other studies have also found that cellular therapies may have a role in combating Treatment Resistant Depression <a href=\"https:\/\/www.mdpi.com\/1999-4923\/15\/3\/814\">[6]<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8474995\/\">[7]<\/a>.<\/p><p>These studies give hope for finding new treatments. With the help of umbilical cord blood cells, those suffering from Treatment Resistant Depression may one day find relief from the debilitating illness affecting their day to day lives.<\/p><p>If you think you may be suffering from depression please speak to your GP.<\/p><p>\u00a0<\/p><p><strong>Organisations who can help if you need someone to talk to:<\/strong><\/p><p><strong>Samaritans: Call 116 123 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>Shout 85258: text SHOUT to 85258 - It\u2019s FREE and available 24\/7<\/strong><\/p><p><strong>CALM: Call 0800 58 58 58 or use their webchat <a href=\"https:\/\/www.thecalmzone.net\/get-support#open-calmbot\">here<\/a>.\u00a0 The helpline and webchat are both open 5pm to midnight, 365 days a year.<\/strong><\/p><p>\u00a0<\/p>","_et_gb_content_width":"","_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[55,60,87,9280],"tags":[9252,9248],"class_list":["post-39005","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-news","category-stem-cell-news","category-stem-cell-therapies","tag-blog","tag-stem-cell-therapy"],"_links":{"self":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/39005","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/users\/1447"}],"replies":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/comments?post=39005"}],"version-history":[{"count":6,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/39005\/revisions"}],"predecessor-version":[{"id":39252,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/posts\/39005\/revisions\/39252"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media\/39006"}],"wp:attachment":[{"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/media?parent=39005"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/categories?post=39005"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cells4life.com\/us\/wp-json\/wp\/v2\/tags?post=39005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}