Cord Blood Stem Cells Treat Sister’s Sickle Cell Anaemia
Sickle cells can cause many problems: the cells do not move as freely through the blood vessels and can cause blockages which result in severe pain. In the UK those with African and Caribbean heritage are most commonly affected by sickle cell anaemia. [1]
The only currently established curative treatment for sickle cell anaemia is a stem cell transplant, and because the condition is genetic, donor stem cells are needed. Carol’s parents were advised to store the cord blood of any future children they should have in hopes of finding a match; siblings have a 25% chance of being a perfect match for transplant.
Research suggests that survival rates are improved when using sibling cord blood compared to unrelated cord blood. Additionally, there is a vast shortage of stem cell donors from black and minority communities. Because of this, Carol’s best chance of finding a stem cell match would be within the family.
Unfortunately, Carol’s condition had deteriorated so much by the time she was six years old that doctors advised her parents that she was in need of a stem cell transplant. Fortunately, Carol’s parents had banked the cord blood of her younger brother Mark and he was a perfect match for Carol.
After undergoing chemotherapy Carol was infused with her brother’s stem cells. Speaking about the transplant Carol said:
“A month after my transplant, testing showed that I was cured of sickle cell disease! I don’t have pain anymore. After my transplant, I started a brand-new life and I’m now a normal and healthy 13-year-old. All kids with sickle cell disease should be able to start a new life too.”[2]
Cells4Life Experience: Blood Disorders
Cells4Life has released samples to be used in the treatment of blood disorders. The patients and donors were siblings.
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