About umbilical cord tissue

Umbilical cord tissue is simply a piece of your baby’s umbilical cord that is collected after the cord blood. It contains billions of stem cells, particularly within the Wharton’s jelly in the cord but also within other regions.

This is why Cells4Life stores the entirety of the tissue sample that we collect. Umbilical cord tissue contains several powerful stem cell types, some of which are unique and not present within the umbilical cord blood.

Storing cord tissue along with cord blood ensures that your child has the maximum range of stem cell types, so that they can take advantage of as many future developments as possible.

Cells4Life is the only UK stem cell storage bank that offers to store you child’s cord blood and cord tissue in multiple samples, providing added security and the possibility that they could be used for multiple treatments in future.

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1. Greatest number of stem cells possible

Some stem cell therapies require the maximum number of stem cells possible in order to increase their chances of success. By choosing our CellsPlus service with cord tissue, you guarantee that your baby has the access to as many cells as possible.

2. Prepared to receive multiple treatments

As your child grows, so too do the number of different and often very common conditions that could be treated using cord blood and cord tissue stem cells. By guaranteeing that you store the maximum number and range of stem cells possible, you ensure that your child is prepared to receive not just one stem cell treatment, but potentially multiple treatments for conditions that we all suffer from as we head into old age.

Ultimately, when you store cord blood and cord tissue together, you can rest assured that your child has the best treatment opportunities available to them, both now and in the future.

The Cells4Life Difference

Stem cells have two crucial properties:

1. the ability to self-renew

2. the ability to differentiate into other cell types

We have been able to demonstrate not just viability, but also that our transportation, processing and cryopreservation methods maintain these properties in the mesenchymal stem cells (MSCs) found in your baby’s umbilical cord tissue.

We were able to do this by isolating MSCs from cord tissue samples that we have collected, expanding them, and then stimulating them to transform into other tissue types.

We successfully grew the main cell types that normally form part of bone, adipose and cartilage tissues, showing our methods retain MSC ‘stemness’. This could be crucial for therapeutic utility.

When you bank umbilical cord tissue with us, you can rest assured that you are making the most of your baby’s stem cells.

Our experiments show:

Umbilical cord tissue samples processed and stored by Cells4Life contain MSCs that can be isolated and expanded into billions of cells

These MSCs can transform into fat, cartilage and bone cellular lineages, demonstrating their ability to differentiate

The Cells4Life Difference

Stem cells have two crucial properties:

1. the ability to self-renew

2. the ability to differentiate into other cell types

We have been able to demonstrate not just viability, but also that our transportation, processing and cryopreservation methods maintain these properties in the mesenchymal stem cells (MSCs) found in your baby’s umbilical cord tissue.

We were able to do this by isolating MSCs from cord tissue samples that we have collected, expanding them, and then stimulating them to transform into other tissue types.

We successfully grew bone, adipose and cartilage tissue, showing our methods retain MSC ‘stemness’. This could be crucial for therapeutic utility.

When you bank cord tissue with us, you can rest assured that you are making the most of your baby’s stem cells.

Our experiments show:

Umbilical cord tissue samples processed and stored by Cells4Life contain MSCs that can be isolated and expanded into billions of cells

These MSCs can transform into fat, cartilage and bone, demonstrating their ability to differentiate

Cord tissue stem cells

Mesenchymal Stem Cells (MSCs)

Like cord blood, the umbilical cord itself is a rich source of mesenchymal stem cells which are found in the “Wharton’s Jelly”. These tissue-forming stem cells are more abundant and powerful than those found in cord blood or adult tissue. They have huge potential for use in regenerative medicine. The MSCs in cord tissue could even be used in organ regeneration treatments – which is perhaps the most exciting area of regenerative medicine of all.

Unique to cord tissue…

Cord tissue contains several unique cell types, which are likely to provide therapies for skin conditions, burns, ulcers and wounds, as well as damage to the eyes and blood vessels.

Human Umbilical Vein Endothelial Cells (HUVECs) 

These cells are easy to culture and are commonly used in research for vascular biology – including inflammation, blood clotting and angiogenesis (the formation of new blood vessels).

Epithelial Cord Lining Stem Cells (CLSCs)

CLSCs have proved effective in treating difficult-to-heal human wounds, such as diabetic ulcers, corneal defects, and have also demonstrated successful regeneration of the liver and heart in animal studies.

Human Umbilical Cord Perivascular Cells (HUCPVCs)

The perivascular cells found in the umbilical cord are being investigated for bone formation and dermal tissue engineering.

What is umbilical cord tissue used for?

Cord tissue is currently being investigated for the treatment of the following conditions:

Why should I store cord tissue as well as cord blood?

By capturing both umbilical cord blood and tissue, you ensure that your child has access to the maximum range and highest number of stem cells possible. This is very important for two key reasons:

1. Greatest number of stem cells possible

Some stem cell therapies require the maximum number of stem cells possible in order to increase their chances of success. By choosing our CellsPlus service with cord tissue, you guarantee that your baby has the access to three times more cells.

2. Prepared to receive multiple treatments

As your child grows, so too do the number of different and often very common conditions that could be treated using cord blood and cord tissue stem cells. By guaranteeing that you store the maximum number and range of stem cells possible, you ensure that your child is prepared to receive not just one stem cell treatment, but potentially multiple treatments for conditions that we all suffer from as we head into old age. Ultimately, when you store cord blood and cord tissue together, you can rest assured that your child has the best treatment opportunities available to them, both now and in the future.

What conditions could be treated using cord blood tissue stem cells? 

Neurological conditions

Neurological conditions 

Scientists at Duke University, North Carolina are treating autistic children with intravenous infusions of cord tissue-derived MSCs.

Heart disease

Heart and vascular disease 

Scientists have seen promising results using MSCs to engineer new cardiac tissue, offering hope to patients suffering from heart failure.

Diabetes

Diabetes

A clinical trial is applying Wharton’s Jelly-derived MSCs to patients with the condition, which affects 415 million people worldwide.

Skeletal conditions

Skeletal conditions

Cord mesenchymal stem cells have been used to treat Multiple Sclerosis, which affects the brain and spinal cord, in clinical trials. Doctors noticed symptom improvements within 1 month.

Cancer

Cancers 

A 2014 study found that umbilical cord tissue MSCs inhibited the growth of tumours linked with prostate cancer, and further research has found similar potential for patients with breast cancer.

Autoimmune

Inflammatory & autoimmune

In Durham, North Carolina, researchers have found that MSCs can treat sepsis, which is an inflammatory condition caused by the body’s overreaction to infection.

Latest news about cord tissue

30 years of cord blood banking: then and now

30 years of cord blood banking: then and now

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Should I store stem cells privately or donate?

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Choosing between public and private cord blood banking can be a daunting decision, especially considering that cord blood collection is a once in a lifetime opportunity only possible at birth. A lot of factors will affect your choice - from the costs to the potential...

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Umbilical cord tissue to treat motor neurone disease

Umbilical cord tissue to treat motor neurone disease

The University of Warmia and Mazury, Poland have announced a trial into the use of cord tissue for treating amyotrophic lateral sclerosis (ALS), a debilitating and life-shortening form of motor neurone disease. Currently, ALS is untreatable and the...

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